Journal ArticleDOI
Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants.
Solvor B. Stølevik,Unni Cecilie Nygaard,Ellen Namork,Margaretha Haugen,Helen Engelstad Kvalem,Helle Margrete Meltzer,Jan Alexander,Joost H.M. van Delft,Henk Van Loveren,Martinus Løvik,Martinus Løvik,Berit Granum +11 more
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TLDR
Prenatal dietary exposure to dioxins and PCBs may increase the risk of wheeze and infectious diseases during the first year of life, and no associations were found between prenatal exposure to acrylamide and the health outcomes investigated.About:
This article is published in Food and Chemical Toxicology.The article was published on 2011-08-01. It has received 65 citations till now. The article focuses on the topics: Wheeze.read more
Citations
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Pre-natal exposure to perfluoroalkyl substances may be associated with altered vaccine antibody levels and immune-related health outcomes in early childhood
Berit Granum,Line Småstuen Haug,Ellen Namork,Solvor B. Stølevik,Cathrine Thomsen,Ingeborg S. Aaberge,Henk Van Loveren,Martinus Løvik,Unni Cecilie Nygaard +8 more
TL;DR: The results indicate that pre-natal exposure to PFAS may be associated with immunosuppression in early childhood.
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Risk for animal and human health related to the presence of dioxins and dioxin???like PCBs in feed and food
Helle Katrine Knutsen,Jan Alexander,Lars Barregård,Margherita Bignami,Beat Johannes Brüschweiler,Sandra Ceccatelli,Bruce Cottrill,Michael Dinovi,Lutz Edler,Bettina Grasl-Kraupp,Christer Hogstrand,Carlo Nebbia,Isabelle P. Oswald,Annette Petersen,Martin Rose,Alain-Claude Roudot,Tanja Schwerdtle,Christiane Vleminckx,Günter Vollmer,Heather M. Wallace,Peter Fürst,Helen Håkansson,Thorhallur I. Halldorsson,Anne-Katrine Lundebye,Raimo Pohjanvirta,Lars Rylander,Andrew Smith,Henk Van Loveren,Ine Waalkens-Berendsen,Marco J. Zeilmaker,Marco Binaglia,Jose Ángel Gómez Ruiz,Zsuzsanna Horvath,Eugen H. Christoph,Laura Ciccolallo,Luisa Ramos Bordajandi,Hans Steinkellner,Laurentius Hoogenboom +37 more
TL;DR: The CONTAM Panel was not able to identify reference values in most farm and companion animals with the exception of NOAELs for mink, chicken and some fish species, and the estimated exposure from feed for these species does not imply a risk.
Journal ArticleDOI
Effects of persistent organic pollutants on the developing respiratory and immune systems: a systematic review.
TL;DR: Current epidemiological evidence suggests that early-life exposure to POPs can adversely influence immune and respiratory systems development, and harmonization of exposure and outcome assessment between studies is recommended.
Journal ArticleDOI
Dietary acrylamide intake during pregnancy and fetal growth-results from the Norwegian mother and child cohort study (MoBa).
Talita Duarte-Salles,Hans von Stedingk,Berit Granum,Kristine B. Gutzkow,Per Rydberg,Margareta Törnqvist,Michelle A. Mendez,Gunnar Brunborg,Anne Lise Brantsæter,Helle Margrete Meltzer,Jan Alexander,Margaretha Haugen +11 more
TL;DR: Lowering dietary acrylamide intake during pregnancy may improve fetal growth and reduce the risk of Down's syndrome in women with small for gestational age (SGA) and birth weight.
Journal ArticleDOI
Exposure of Norwegian toddlers to perfluoroalkyl substances (PFAS): The association with breastfeeding and maternal PFAS concentrations
Eleni Papadopoulou,Azemira Sabaredzovic,Ellen Namork,Unni Cecilie Nygaard,Berit Granum,Line Småstuen Haug +5 more
TL;DR: The findings suggest that transplacental transfer, prenatally, and breastfeeding, postanatally, are among the main determinants of PFOS, PFOA, PFHxS and PFHpS concentrations in toddlers, while that was not the case for PFNA and PFUnDA.
References
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The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.
Martin van den Berg,Linda S. Birnbaum,Michael S. Denison,Mike De Vito,William H. Farland,Mark Feeley,Heidelore Fiedler,Helen Håkansson,Annika Hanberg,Laurie C. Haws,Martin Rose,Stephen Safe,Dieter Schrenk,Chiharu Tohyama,Angelika Tritscher,Jouko Tuomisto,Mats Tysklind,Nigel J. Walker,Richard E. Peterson +18 more
TL;DR: Concern was expressed about direct application of the TEF/total toxic equivalency (TEQ) approach to abiotic matrices, such as soil, sediment, etc., for direct application in human risk assessment as the present TEF scheme and TEQ methodology are primarily intended for estimating exposure and risks via oral ingestion.
Journal ArticleDOI
Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife
M. van den Berg,L. Birnbaum,A.T.C. Bosveld,B. Brunstrom,P. Cook,M. Feeley,John P. Giesy,Annika Hanberg,R. Hasegawa,S.W. Kennedy,T. Kubiak,J. C. Larsen,F.X.R. van Leeuwen,A. K. D. Liem,C. Nolt,R.E. Peterson,L. Poellinger,Stephen Safe,D. Schrenk,D. Tillitt,Mats Tysklind,Maged Younes,F. Waern,T. Zacharewski +23 more
TL;DR: It was concluded that the TEF concept is still the most plausible and feasible approach for risk assessment of halogenated aromatic hydrocarbons with dioxinlike properties.
Journal ArticleDOI
Acrylamide is formed in the Maillard reaction
TL;DR: It is shown how acrylamide can be generated from food components during heat treatment as a result of the Maillard reaction between amino acids and reducing sugars.
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Control of T reg and T H 17 cell differentiation by the aryl hydrocarbon receptor
Francisco J. Quintana,Alexandre S. Basso,Antonio Iglesias,Thomas Korn,Mauricio F. Farez,Estelle Bettelli,Mario Caccamo,Mohamed Oukka,Howard L. Weiner +8 more
TL;DR: The identification of the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) as a regulator of Treg and TH17 cell differentiation in mice is reported, constituting a unique target for therapeutic immunomodulation.
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Acrylamide from Maillard reaction products
Richard H. Stadler,Imre Blank,Natalia Varga,Fabien Robert,Jörg Hau,Philippe A. Guy,Marie-Claude Robert,Sonja Riediker +7 more
TL;DR: It is shown that acrylamide can be released by the thermal treatment of certain amino acids (asparagine, for example), particularly in combination with reducing sugars, and of early Maillard reaction products (N-glycosides).