Journal ArticleDOI
Prevalence of rheumatologist-diagnosed psoriatic arthritis in patients with psoriasis in European/North American dermatology clinics
Philip J. Mease,Dafna D. Gladman,Kim A. Papp,Majed Khraishi,Diamant Thaçi,F. Behrens,Robert Northington,Joanne Fuiman,Eustratios Bananis,R. Boggs,Daniel F. Alvarez +10 more
TLDR
Almost a third of patients with psoriasis seen in dermatology centers had PsA as determined by rheumatologists, and more than a third had not been previously given the diagnosis.Abstract:
Background Prompt identification and treatment of psoriatic arthritis (PsA) in patients with psoriasis is critical to reducing the risk of joint damage, disability, and comorbidities. Objective We sought to estimate PsA prevalence in patients with plaque psoriasis in 34 dermatology centers in 7 European and North American countries. Methods Consecutive patients were evaluated by dermatologists for plaque psoriasis and subsequently by rheumatologists for PsA. PsA prevalence was estimated primarily based on rheumatologists' assessment of medical history, physical examination, and laboratory tests. Results Of 949 patients evaluated, 285 (30%) had PsA (95% confidence interval 27-33) based on rheumatologists' assessment. PsA diagnosis changed in 1.2% of patients when diagnostic laboratory tests were added to medical history and physical examination. Of 285 patients given the diagnosis of PsA, 117 (41%) had not been previously given the diagnosis. Limitations Bias may have been introduced by lack of standardized diagnostic criteria and unbalanced recruitment based on country populations. Conclusions In this study, almost a third of patients with psoriasis seen in dermatology centers had PsA as determined by rheumatologists. More than a third of patients with PsA had not been previously given the diagnosis. Clinical evaluation alone is often sufficient basis for PsA diagnosis, but laboratory test results may be helpful in some patients.read more
Citations
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Journal ArticleDOI
Psoriasis Pathogenesis and Treatment.
Adriana Rendon,Knut Schäkel +1 more
TL;DR: The role of genetics, associated epigenetic mechanisms, and the interaction of the skin flora in the pathophysiology of psoriasis is described, which includes a comprehensive review of well-established widely available therapies and novel targeted drugs.
Journal ArticleDOI
Psoriasis and comorbid diseases: Epidemiology.
Junko Takeshita,Sungat K. Grewal,Sinead Langan,Nehal N. Mehta,Alexis Ogdie,Abby S. Van Voorhees,Joel M. Gelfand +6 more
TL;DR: A rapidly expanding body of literature in various populations and settings supports additional associations between psoriasis and cardiometabolic diseases, gastrointestinal diseases, kidney disease, malignancy, infection, and mood disorders.
Journal ArticleDOI
Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics.
Alan Menter,Bruce Strober,Daniel H. Kaplan,Dario Kivelevitch,Elizabeth Farley Prater,Benjamin K. Stoff,April W. Armstrong,Cody Connor,Kelly M. Cordoro,Dawn Marie R. Davis,Boni E. Elewski,Joel M. Gelfand,Kenneth B. Gordon,Alice B. Gottlieb,Arthur Kavanaugh,Matthew Kiselica,Neil J. Korman,Daniela Kroshinsky,Mark Lebwohl,Craig L. Leonardi,Jason Lichten,Henry W. Lim,Nehal N. Mehta,Amy S. Paller,Sylvia L. Parra,Arun L. Pathy,Reena N. Rupani,Michael Siegel,Emily B. Wong,Jashin J. Wu,Vidhya Hariharan,Craig A. Elmets +31 more
TL;DR: The treatment of psoriasis with biologic agents will be reviewed, emphasizing treatment recommendations and the role of the dermatologist in monitoring and educating patients regarding benefits as well as associated risks.
Journal ArticleDOI
Effect of certolizumab pegol on signs and symptoms in patients with psoriatic arthritis: 24-week results of a Phase 3 double-blind randomised placebo-controlled study (RAPID-PsA).
Philip J. Mease,Roy Fleischmann,A. Deodhar,Jürgen Wollenhaupt,Majed Khraishi,D. Kielar,F. Woltering,C. Stach,Bengt Hoepken,T. Arledge,D. van der Heijde +10 more
TL;DR: Rapid improvements in the signs and symptoms of PsA, including joints, skin, enthesitis, dactylitis and nail disease were observed across both CZP dosing regimens, independent of prior TNF inhibitor exposure.
Journal ArticleDOI
Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a population-based cohort study
Alexis Ogdie,YiDing Yu,Kevin Haynes,Thorvardur Jon Love,Samantha G. Maliha,Yihui Jiang,Andrea B. Troxel,Sean Hennessy,Stephen E. Kimmel,David J. Margolis,Hyon K. Choi,Nehal N. Mehta,Joel M. Gelfand +12 more
TL;DR: Cardiovascular risk should be addressed with all patients affected by psoriasis, PsA or RA and an interaction between disease status and disease-modifying antirheumatic drug (DMARD) use is hypothesised.
References
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Journal ArticleDOI
Psoriatic arthritis: epidemiology, clinical features, course, and outcome
TL;DR: It is important to note that patients included in recent drug trials resemble patients followed prospectively in a clinic, and patients with PsA who present with polyarticular disease are at risk for disease progression.
Journal Article
The Impact of Psoriasis on Quality of Life: Results of a 1998 National Psoriasis Foundation Patient-Membership Survey
TL;DR: The unprecedented response to the survey provides compelling evidence that individuals with psoriasis believe that the disease has a profound emotional and social as well as physical impact on their quality of life.
Journal ArticleDOI
Epidemiology of psoriatic arthritis in the population of the United States.
Joel M. Gelfand,Dafna D. Gladman,Philip J. Mease,Nana Smith,David J. Margolis,Tamar Nijsten,Robert S. Stern,Steven R. Feldman,Tara Rolstad +8 more
TL;DR: The prevalence of psoriatic arthritis among patients with psoriasis was 11% (95% CI: 9%, 14%) and varied substantially based on self-reporting of the extent of skin involvement with Psoriasis, which demonstrates the importance of performing broadly representative studies to measure the prevalence.
Journal ArticleDOI
Epidemiology and clinical pattern of psoriatic arthritis in Germany: a prospective interdisciplinary epidemiological study of 1511 patients with plaque-type psoriasis
TL;DR: This poster discusses how best to select a dermatologist for the initial diagnosis of psoriatic arthritis based on the individual patient's history, symptoms, and once-and-a-half-year-old to six-month-old twins.
Journal ArticleDOI
Health-related quality of life of patients with psoriatic arthritis: a comparison with patients with rheumatoid arthritis.
TL;DR: It appeared that there may be unique disabilities associated with the psoriasis dimension of PsA, and there were some meaningful differences in how the 2 conditions affect health-related QOL.
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