Journal ArticleDOI
Primidone oxidation catalyzed by metalloporphyrins and Jacobsen catalyst
T.C.O. Mac Leod,André Luiz de Faria,Vicente Pereira de Barros,Maria Eugênia Costa Queiroz,Marilda das Dores Assis +4 more
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TLDR
In this article, the primidone (PRM) oxidation by various oxidants such as iodosylbenzene (PhIO), tert -butyl hydroperoxide 70.1% (TOOH), 3-chloroperoxybenzoic acid (m -CPBA) and hydrogen peroxide 30.1 % mediated by either a salen complex or metalloporphyrins was investigated.Abstract:
Primidone (PRM) oxidation by various oxidants such as iodosylbenzene (PhIO), tert -butyl hydroperoxide 70 wt.% ( t -BOOH), 3-chloroperoxybenzoic acid ( m -CPBA) and hydrogen peroxide 30 wt.%, mediated by either a salen complex or metalloporphyrins, was investigated. The catalytic systems led to phenylethylmalondiamide (PEMA) and phenobarbital (FENO), the same metabolites obtained in vivo with P450 enzymes, although three other products were also detected. Product formation was highly dependent on the oxidant, co-catalyst (imidazole), pH and dioxygen. These biomimetic chemical models have potential application in the synthesis of drug metabolites, which should provide samples for pharmacological tests. They can also be employed in studies that pursue the elucidation of in vivo drug metabolism.read more
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Journal ArticleDOI
Attenuation of pharmaceutically active compounds in aqueous solution by UV/CaO2 process: Influencing factors, degradation mechanism and pathways.
Ming Zheng,Kevin D. Daniels,Minkyu Park,Alec Brockway Nienhauser,Erica C. Clevenger,Yongmei Li,Shane A. Snyder,Shane A. Snyder +7 more
TL;DR: The effective removal of CBZ and PMD in a secondary wastewater effluent by UV/CaO2 treatment demonstrates the potential use of this AOP technology in advanced treatment of wastewater-derived PhACs.
Journal ArticleDOI
Biomimetic in vitro oxidation of lapachol: a model to predict and analyse the in vivo phase I metabolism of bioactive compounds.
Michael Niehues,Valeria Priscila de Barros,Flavio da Silva Emery,Marcelo Dias-Baruffi,Marilda das Dores Assis,Norberto Peporine Lopes +5 more
TL;DR: The biomimetic model with a manganese salen complex has evidenced its use as a valuable tool to predict and elucidate the in vivo phase I metabolism of lapachol and possibly also of other bioactive natural compounds.
Journal ArticleDOI
Biomimetic oxidation of piperine and piplartine catalyzed by iron(III) and manganese(III) porphyrins.
Estela Hanauer Schaab,Antônio Eduardo Miller Crotti,Yassuko Iamamoto,Massuo J. Kato,Letícia Veras Costa Lotufo,Norberto Peporine Lopes +5 more
TL;DR: The oxidation of piperine and piplartine by iodosylbenzene using iron( III) and manganese(III) porphyrins yielded mono- and dihydroxylated products, respectively.
Journal ArticleDOI
CYP-450 isoenzymes catalyze the generation of hazardous aromatic amines after reaction with the azo dye Sudan III.
Thalita B. Zanoni,Thiago Mescoloto Lizier,Marilda das Dores Assis,Maria Valnice Boldrin Zanoni,Danielle Palma de Oliveira +4 more
TL;DR: Findings clearly indicate that aromatic amines are formed due to oxidative reactions that can be promoted by hepatic cells, after the ingestion of Sudan III, an adulterant food dye, and should be carefully controlled.
Journal ArticleDOI
In vitro metabolism study of the promising anticancer agent the lignan (-)-grandisin.
Gisele Baraldi Messiano,Renan Augusto da Silva Santos,Leandro de Santis Ferreira,Rodrigo Almeida Simões,Rodrigo Almeida Simões,Valquíria A. P. Jabor,Massuo J. Kato,Norberto Peporine Lopes,Mônica Tallarico Pupo,Anderson Rodrigo Moraes de Oliveira +9 more
TL;DR: The biotransformation of dihydro-grandisin, characterized by GC-MS, by mammalian systems indicated the involvement of a CYP450 enzyme type, and a simple, sensitive and selective HPLC method was developed and fully validated.
References
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Book
Cytochrome P-450: Structure, Mechanism, and Biochemistry
Ortiz de Montellano,R Paul +1 more
TL;DR: The Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids in Plants and the Diversity and Importance of Microbial Cytochromes P450 are studied.
Journal ArticleDOI
Metalloporphyrins as versatile catalysts for oxidation reactions and oxidative DNA cleavage
Journal ArticleDOI
Structure and Chemistry of Cytochrome P450
TL;DR: This review will concentrate on findings with P-450cam of the Pseudomonas putida camphor-5-exo-hydroxylase, and attention will be drawn to parallel and contrasting examples from other P- 450s as appropriate.
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