Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?
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TLDR
Evaluation of commercially available methods for measuring OT reveals that they lack reliability when used on unextracted samples of human fluids, and that they tag molecules in addition to OT, yielding estimates that are wildly discrepant with an extensive body of earlier findings.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2013-09-01 and is currently open access. It has received 365 citations till now.read more
Citations
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Oxytocin for Male Subjects with Autism Spectrum Disorder and Comorbid Intellectual Disabilities: A Randomized Pilot Study.
Toshio Munesue,Hiroyuki Nakamura,Mitsuru Kikuchi,Yui Miura,Noriyuki Takeuchi,Tokie Anme,Eiji Nanba,Kaori Adachi,Kiyotaka Tsubouchi,Yoshimichi Sai,Ken-ichi Miyamoto,Shin-ichi Horike,Shigeru Yokoyama,Hideo Nakatani,Yo Niida,Hirotaka Kosaka,Yoshio Minabe,Haruhiro Higashida +17 more
TL;DR: It is demonstrated that long-term administration of intranasal OXT is tolerable in a representative cohort of ASD individuals with ID and suggests that future multicenter trials of OXT are warranted and should include measurements of reciprocal social interactions based on daily life under closer surveillance for epilepsy.
Journal ArticleDOI
Beyond the hype and hope: Critical considerations for intranasal oxytocin research in autism spectrum disorder.
TL;DR: There remains significant potential for oxytocin to ameliorate aspects of the persistent and debilitating social impairments in individuals with ASD, and an urgent need to prioritise considering such factors when conducting well‐designed and controlled studies to further advance this field.
Journal ArticleDOI
How the brain codes intimacy: The neurobiological substrates of romantic touch.
Ann-Kathrin Kreuder,Dirk Scheele,Lea Wassermann,Michael Wollseifer,Birgit Stoffel-Wagner,Mary R. Lee,Juergen Hennig,Wolfgang Maier,Wolfgang Maier,René Hurlemann +9 more
TL;DR: The results suggest that OXT may contribute to the maintenance of monogamous relationships in humans by concomitantly increasing the reward value of partner touch and diminishing the hedonic quality of stranger touch.
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Breast cancer and social environment: getting by with a little help from our friends
TL;DR: It is proposed that social environment contributes to the vast individual differences in prognosis among breast cancer survivors because social environment is capable of altering basic physiological processes, which in turn can modulate tumor growth.
Journal ArticleDOI
Metabolic Effects of Oxytocin.
TL;DR: The physiologic effects of OXT on metabolism and its therapeutic potential for metabolic disorders are summarized and future randomized, placebo-controlled clinical trials in humans should include rigorous, standardized, and detailed assessments.
References
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Bioanalytical method validation--a revisit with a decade of progress.
Vinod P. Shah,Kamal K. Midha,John W. A. Findlay,Howard Hill,James D. Hulse,Iain J. McGilveray,Gordon McKay,Krys J. Miller,Rabindra Patnaik,Mark L. Powell,Alfred P. Tonelli,C. T. Viswanathan,Avraham Yacobi +12 more
TL;DR: The purpose of this report is to represent the progress in analytical methodologies over the last decade and assessment of the major agreements and issues discussed with regard to small molecules at both the conference and the workshop.
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Oxytocin, vasopressin, and the neurogenetics of sociality.
Zoe R. Donaldson,Larry J. Young +1 more
TL;DR: There is growing evidence that the neuropeptides oxytocin and vasopressin modulate complex social behavior and social cognition and suggest that variation in the genes encoding their receptors may contribute to variation in human social behavior by altering brain function.
Journal ArticleDOI
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
TL;DR: OXT and AVP are emerging as targets for novel treatment approaches — particularly in synergistic combination with psychotherapy — for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia.
Journal ArticleDOI
The Diagnostic Applications of Saliva— A Review:
Eliaz Kaufman,Ira B. Lamster +1 more
TL;DR: Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.
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Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Inga D. Neumann,Rainer Landgraf +1 more
TL;DR: Shifting the balance between the neuropeptide systems towards oxytocin, by positive social stimuli and/or psychopharmacotherapy, may help to improve emotional behaviors and reinstate mental health.
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