Journal ArticleDOI
Progesterone and Medroxyprogesterone Acetate Effects on Central and Peripheral Allopregnanolone and Beta-Endorphin Levels
F Bernardi,Nicola Pluchino,Matteo Pieri,Silvia Begliuomini,Elena Lenzi,Simone Puccetti,Elena Casarosa,Michele Luisi,Andrea R. Genazzani +8 more
TLDR
It is demonstrated that progesterone and MPA have a similar but not identical effect on central and peripheral allopregnanolone and β-END levels and their association with an estrogenic compound does not interfere with the positive effects produced by estrogen.Abstract:
The increased use of hormonal therapies has led to the study of the properties of different progestin molecules and their effects on the central nervous system. The central and peripheral levels of neread more
Citations
More filters
Journal ArticleDOI
Progesterone exerts neuroprotective effects after brain injury.
TL;DR: This review assesses recent, primarily in vivo, evidence that progesterone can play an important role in promoting and enhancing repair after traumatic brain injury and stroke.
Journal ArticleDOI
Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system.
Michael Schumacher,Rachida Guennoun,Abdel M. Ghoumari,Charbel Massaad,Françoise Robert,Martine El-Etr,Yvette Akwa,Krzysztof Rajkowski,Etienne-Emile Baulieu +8 more
TL;DR: The utility and safety of postmenopausal hormone replacement therapy has recently been put into question by large clinical trials, and the recognition that progesterone is synthesized by neurons and glial cells requires a reevaluation of hormonal aging.
Journal ArticleDOI
A prospective one-year study of estrogen and progestin in postmenopausal women: Effects on clinical symptoms and lipoprotein lipids
Barbara B. Sherwin,Gelfand Mm +1 more
TL;DR: In this paper, the effects of different doses of oral estrogen and progestin, administered sequentially, on clinical symptoms and lipid metabolism provide guidelines for the treatment of postmenopausal women.
Journal ArticleDOI
Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some persons.
Torbjörn Bäckström,David Haage,Mats Löfgren,Inga-Maj Johansson,Jessica Strömberg,Sigrid Nyberg,Lotta Andréen,Lindsey Ossewaarde,G.A. van Wingen,G.A. van Wingen,Sahruh Turkmen,Sara K. Bengtsson +11 more
TL;DR: Some women have negative mood symptoms, caused by progestagens in hormonal contraceptives or sequential hormone therapy or by progesterone in the luteal phase of the menstrual cycle as mentioned in this paper.
Journal ArticleDOI
Could transdermal estradiol + progesterone be a safer postmenopausal HRT? A review.
TL;DR: While all types of hormone replacement therapies are safe and effective and confer significant benefits in the long-term when initiated in young postmenopausal women, in specific clinical settings the choice of the transdermal route of administration of estrogens and the use of natural progesterone might offer significant benefits and added safety.
References
More filters
Journal ArticleDOI
Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance.
TL;DR: The abundant CNS cholesterol and its sulfate derivative serve as precursors of different neurosteroids, which bidirectionally modulate neuronal excitability, by potentiating or inhibiting function of the GABAA receptors.
Journal ArticleDOI
Pharmacology of estrogens and progestogens: influence of different routes of administration.
TL;DR: This review comprises the pharmacokinetics and pharmacodynamics of natural and synthetic estrogens and progestogens used in contraception and therapy, with special consideration of hormone replacement therapy.
Journal ArticleDOI
Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABAA Receptors
TL;DR: Evidence is provided that the anxiolytic effect of PROG is not associated with an intracellular steroid receptor that initiates genomic‐mediated responses, and is consistent with a nongenomic mechanism whereby PROG is metabolized to allopregnanolone, a neuroactive steroid that potentiates GABAA receptor‐ mediated responses.
Journal ArticleDOI
The Neurosteroids Progesterone and Allopregnanolone Reduce Cell Death, Gliosis, and Functional Deficits after Traumatic Brain Injury in Rats
TL;DR: Evidence of the anti-apoptotic and anti-astrogliotic effects of progesterone and allopregnanolone are provided and help to explain why better cognitive performance is observed after injury when animals are given either neurosteroid.
Journal ArticleDOI
Circulating Levels of Allopregnanolone in Humans: Gender, Age, and Endocrine Influences
Ar Genazzani,Felice Petraglia,F Bernardi,Elena Casarosa,C Salvestroni,A. Tonetti,Rossella E. Nappi,Stefano Luisi,Marco Palumbo,Robert H. Purdy,M. Luisi +10 more
TL;DR: It is demonstrated that although men show an age-related decrease, serum allopregnanolone levels in women do not change with age and correlate with P levels during the menstrual cycle and in response to endocrine tests.
Related Papers (5)
Anxiolytic Effect of Progesterone is Mediated by the Neurosteroid Allopregnanolone at Brain GABAA Receptors
Impact of progestins on estrogen-induced neuroprotection: Synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate
Jon Nilsen,Roberta Diaz Brinton +1 more