Journal ArticleDOI
Prognostic and Therapeutic Implications of Circulating Androgen Receptor Gene Copy Number in Prostate Cancer Patients Using Droplet Digital Polymerase Chain Reaction.
Sarah Buelens,Sarah Buelens,Tom Claeys,Bert Dhondt,Bert Dhondt,Filip Poelaert,Filip Poelaert,Matthijs Vynck,Nurten Yigit,Olivier Thas,Olivier Thas,Piet Ost,Piet Ost,Jo Vandesompele,Nicolaas Lumen,Nicolaas Lumen,Candy Kumps +16 more
TLDR
In this paper, the authors evaluated the circulating AR gene copy number (CN) gain using droplet digital polymerase chain reaction in 21 control and 91 prostate cancer serum samples and its prognostic and therapeutic implications in prostate cancer.About:
This article is published in Clinical Genitourinary Cancer.The article was published on 2017-12-01. It has received 9 citations till now. The article focuses on the topics: Enzalutamide & Prostate cancer.read more
Citations
More filters
Journal ArticleDOI
Liquid biopsy and PCR-free ultrasensitive detection systems in oncology (Review)
Alessia Finotti,Matteo Allegretti,Jessica Gasparello,Patrizio Giacomini,Demetrios A. Spandidos,Giuseppe Spoto,Roberto Gambari +6 more
TL;DR: This review lists some major applicative areas, briefly addresses how technology is bypassing liquid biopsy limitations, and places a particular emphasis on novel, PCR-free platforms.
Journal ArticleDOI
Current and Emerging Applications of Droplet Digital PCR in Oncology: An Updated Review.
TL;DR: A review of liquid biopsy methods for tumor genotyping can be found in this paper, where the authors provide a general overview of the major applications of liquid-biopsy in blood, including its utility for molecular response and minimal residual disease monitoring.
Journal ArticleDOI
A Systematic Review and Meta-Analysis on the Predictive Value of Cell-Free DNA–Based Androgen Receptor Copy Number Gain in Patients With Castration-Resistant Prostate Cancer
Sofie H. Tolmeijer,Emmy Boerrigter,Jack A. Schalken,Maartje J. Geerlings,Inge M. van Oort,Nielka P. van Erp,Winald R. Gerritsen,Marjolijn J. L. Ligtenberg,Niven Mehra +8 more
TL;DR: This data indicates that androgen receptor copy number gain detected in cell-free DNA (cfDNA) can predict treatment response to androgen receptors signaling inhibitors (ARSIs) in women with high levels of testosterone.
Journal ArticleDOI
Abiraterone and spironolactone in prostate cancer: a combination to avoid.
Bert Dhondt,Bert Dhondt,Sarah Buelens,Jeroen Van Besien,Matthias Beysens,Elise De Bleser,Elise De Bleser,Piet Ost,Piet Ost,Nicolaas Lumen +9 more
TL;DR: Although spironolactone generally exerts anti-androgenic effects, experimental evidence exists that it acts as an androgens receptor agonist in an androgen-depleted environment, capable of inducing prostate cancer proliferation and should be avoided in prostate cancer patients suffering from treatment-associated side effects of abiraterone.
Journal ArticleDOI
Clinical Applications of Liquid Biopsy in Prostate Cancer: From Screening to Predictive Biomarker
TL;DR: Common clinical scenarios are considered to describe available LB assays in PC as a platform to explore existing evidence for their use in guiding decision making and to discuss current limitations to their adoption in the clinic.
References
More filters
Journal Article
R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI
Abiraterone and Increased Survival in Metastatic Prostate Cancer
Johann S. de Bono,Christopher J. Logothetis,Arturo Molina,Karim Fizazi,Scott North,Luis Chu,Kim N. Chi,Robert Jones,Oscar B. Goodman,Fred Saad,John Staffurth,Paul N. Mainwaring,S. J. Harland,Thomas W. Flaig,Thomas E. Hutson,Tina Cheng,Helen Patterson,John D. Hainsworth,Charles J. Ryan,Cora N. Sternberg,Susan Ellard,Aude Flechon,Mansoor N. Saleh,Mark C. Scholz,Eleni Efstathiou,Andrea Zivi,Diletta Bianchini,Yohann Loriot,Nicole Chieffo,Thian Kheoh,Christopher M. Haqq,Howard I. Scher +31 more
TL;DR: The inhibition of androgen biosynthesis by abiraterone acetate prolonged overall survival among patients with metastatic castration-resistant prostate cancer who previously received chemotherapy.
Journal ArticleDOI
Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy
Howard I. Scher,Karim Fizazi,Fred Saad,Mary-Ellen Taplin,Cora N. Sternberg,Kurt Miller,Ronald de Wit,Peter F.A. Mulders,Kim N. Chi,Neal D. Shore,Andrew J. Armstrong,Thomas W. Flaig,Aude Flechon,Paul N. Mainwaring,Mark D. Fleming,John D. Hainsworth,Mohammad Hirmand,Bryan Selby,Lynn Seely,Johann S. de Bono,B Ch +20 more
TL;DR: Enzalutamide significantly prolonged the survival of men with metastatic castration-resistant prostate cancer after chemotherapy, and was shown with respect to all secondary end points.
Journal ArticleDOI
Enzalutamide in Metastatic Prostate Cancer before Chemotherapy
Tomasz M. Beer,Andrew J. Armstrong,Dana E. Rathkopf,Yohann Loriot,Cora N. Sternberg,Celestia S. Higano,Peter Iversen,Suman Bhattacharya,Joan Carles,Simon Chowdhury,Ian D. Davis,Johann S. de Bono,Christopher P. Evans,Karim Fizazi,Anthony M. Joshua,Choung-Soo Kim,Go Kimura,Paul N. Mainwaring,Harry H. Mansbach,Kurt Miller,Sarah B. Noonberg,Frank Perabo,De Phung,Fred Saad,Howard I. Scher,Mary-Ellen Taplin,Peter Venner,Bertrand Tombal +27 more
TL;DR: Enzalutamide significantly decreased the risk of radiographic progression and death and delayed the initiation of chemotherapy in men with metastatic prostate cancer.
Journal ArticleDOI
Molecular determinants of resistance to antiandrogen therapy
Charlie D. Chen,Derek S. Welsbie,Chris Tran,Sung Hee Baek,Randy Chen,Robert L. Vessella,Michael G. Rosenfeld,Charles L. Sawyers +7 more
TL;DR: Using microarray-based profiling of isogenic prostate cancer xenograft models, it is found that a modest increase in androgen receptor mRNA was the only change consistently associated with the development of resistance to antiandrogen therapy.
Related Papers (5)
Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance in castration-resistant prostate cancer
Arun Azad,Stanislav Volik,Alexander W. Wyatt,Anne Haegert,Stephane Le Bihan,Robert H. Bell,Shawn Anderson,Brian McConeghy,Robert Shukin,Jenny Bazov,Jack F. Youngren,Pamela L. Paris,George Thomas,Eric J. Small,Yuzhuo Wang,Yuzhuo Wang,Martin E. Gleave,Martin E. Gleave,Colin Collins,Colin Collins,Kim N. Chi,Kim N. Chi +21 more
Androgen receptor mutations in patients with castration-resistant prostate cancer treated with apalutamide.
Dana E. Rathkopf,Matthew R. Smith,Charles J. Ryan,William R. Berry,N.D. Shore,Glenn Liu,Celestia S. Higano,Joshi J. Alumkal,Ralph J. Hauke,Ronald F. Tutrone,Mansoor N. Saleh,E. Chow Maneval,Shibu Thomas,Deborah Ricci,Margaret K. Yu,C. J. de Boer,A. Trinh,Thian Kheoh,Rajesh Bandekar,Howard I. Scher,Emmanuel S. Antonarakis +20 more