Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation
Philippe Armand,Haesook T. Kim,Corey Cutler,Vincent T. Ho,John Koreth,Edwin P. Alyea,Robert J. Soiffer,Joseph H. Antin +7 more
TLDR
The results argue that iron overload plays an important role in transplantation outcome for patients with acute leukemia or MDS, as it does in thalassemia and suggest future prospective trials to examine the potential benefit of chelation therapy in this setting.About:
This article is published in Blood.The article was published on 2007-05-15 and is currently open access. It has received 384 citations till now. The article focuses on the topics: Transplantation & Myelodysplastic syndromes.read more
Citations
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Journal ArticleDOI
Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet
Luca Malcovati,Eva Hellström-Lindberg,David G. Bowen,Lionel Ades,Jaroslav Cermak,Consuelo del Cañizo,Matteo G. Della Porta,Pierre Fenaux,Norbert Gattermann,Ulrich Germing,Joop H. Jansen,Moshe Mittelman,Ghulam J. Mufti,Uwe Platzbecker,Guillermo Sanz,Dominik Selleslag,Mette Skov-Holm,Reinhard Stauder,Argiris Symeonidis,Arjan A. van de Loosdrecht,Theo de Witte,Mario Cazzola +21 more
TL;DR: Within the myelodysplastic syndrome (MDS) work package of the European LeukemiaNet, an Expert Panel was selected according to the framework elements of the National Institutes of Health Consensus Development Program and Guidelines were developed on the basis of a list of patient- and therapy-oriented questions.
Journal ArticleDOI
Guidelines for the diagnosis and management of adult aplastic anaemia.
Sally Killick,Nick Bown,Jamie Cavenagh,Inderjeet Dokal,Theodora Foukaneli,Anita J. Hill,Peter Hillmen,Robin M. Ireland,Austin G. Kulasekararaj,Ghulam J. Mufti,John A. Snowden,Sujith Samarasinghe,Anna Wood,Judith C. W. Marsh +13 more
TL;DR: The authors thank Sally B. Killick, Nick Bown, Jamie Cavenagh, Inderjeet Dokal, Theodora Foukaneli, Peter Hillmen, Robin Ireland, Austin Kulasekararaj, Ghulam Mufti, John A Snowden, Sujith Samarasinghe and Anna Wood for their help.
Journal ArticleDOI
Ferritin for the Clinician
TL;DR: Ferritin is directly implicated in less common but potentially devastating human diseases including sideroblastic anemias, neurodegenerative disorders, and hemophagocytic syndrome and recent research describes novel functions of ferritin independent of iron storage.
Journal ArticleDOI
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples
TL;DR: This work highlights specifically the role of iron metabolism, and the detailed speciation of iron, in chemical and other toxicology, and has significant implications for the use of iron chelating substances as nutritional or therapeutic agents in inhibiting both the progression of these mainly degenerative diseases and the sequelae of both chronic and acute toxin exposure.
Journal ArticleDOI
Somatic Mutations Predict Poor Outcome in Patients With Myelodysplastic Syndrome After Hematopoietic Stem-Cell Transplantation
Rafael Bejar,Kristen E. Stevenson,Bennett A. Caughey,R. Coleman Lindsley,Brenton G. Mar,Petar Stojanov,Gad Getz,David P. Steensma,Jerome Ritz,Robert J. Soiffer,Joseph H. Antin,Edwin P. Alyea,Philippe Armand,Vincent T. Ho,John Koreth,Donna Neuberg,Corey Cutler,Benjamin L. Ebert +17 more
TL;DR: Mutations in TP53, TET2, or DNMT3A identify patients with MDS with shorter OS after HSCT, and these mutations were associated with decreased OS in univariable and multivariable analyses.
References
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A Proportional Hazards Model for the Subdistribution of a Competing Risk
Jason P. Fine,Robert Gray +1 more
TL;DR: This article proposes methods for combining estimates of the cause-specific hazard functions under the proportional hazards formulation, but these methods do not allow the analyst to directly assess the effect of a covariate on the marginal probability function.
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Survival in medically treated patients with homozygous beta-thalassemia.
Nancy F. Olivieri,David G. Nathan,James H. MacMillan,Alan S. Wayne,Peter P. Liu,Allison McGee,Marie Martin,Gideon Koren,Alan R. Cohen +8 more
TL;DR: Univariate analysis demonstrated that factors affecting cardiac disease-free survival were age at the start of chelation therapy and life-table analysis to estimate freedom from cardiac disease over time.
Journal ArticleDOI
Bone Marrow Transplantation in Patients with Thalassemia
Guido Lucarelli,Maria Galimberti,Paola Polchi,Emanuele Angelucci,Donatella Baronciani,Claudio Giardini,Politi P,Durazzi Sm,Muretto P,F. Albertini +9 more
TL;DR: It is concluded that for patients under 16 years of age, transplantation of bone marrow from an HLA-identical donor offers a high probability of complication-free survival, particularly if they do not have hepatomegaly or portal fibrosis.
Journal ArticleDOI
Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major.
Nancy F. Olivieri,Gary M. Brittenham,Christine E. McLaren,Douglas M. Templeton,Ross G. Cameron,Robert A. McClelland,Alastair D. Burt,Kenneth A. Fleming +7 more
TL;DR: Deferiprone does not adequately control body iron burden in patients with thalassemia and may worsen hepatic fibrosis.
Journal ArticleDOI
Marrow Transplantation in Patients with Thalassemia Responsive to Iron Chelation Therapy
Guido Lucarelli,Maria Galimberti,Paola Polchi,Emanuele Angelucci,Donatella Baronciani,Claudio Giardini,Marco Andreani,F Agostinelli,F. Albertini,Reginald A. Clift +9 more
TL;DR: The high probability of cure with little early or late morbidity and mortality suggests that patients with class 1 thalassemia who have HLA-identical donors available should be treated by bone marrow transplantation.
Related Papers (5)
Prognostic impact of pre-transplantation transfusion history and secondary iron overload in patients with myelodysplastic syndrome undergoing allogeneic stem cell transplantation: a GITMO study
Emilio Paolo Alessandrino,Matteo G. Della Porta,Andrea Bacigalupo,Luca Malcovati,Emanuele Angelucci,Maria Teresa Van Lint,Michele Falda,Francesco Onida,Massimo Bernardi,Stefano Guidi,Barbarella Lucarelli,Alessandro Rambaldi,Raffaella Cerretti,Paola Marenco,Pietro Pioltelli,Cristiana Pascutto,Rosi Oneto,Laura Pirolini,Renato Fanin,Alberto Bosi +19 more