Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet
Luca Malcovati,Eva Hellström-Lindberg,David G. Bowen,Lionel Ades,Jaroslav Cermak,Consuelo del Cañizo,Matteo G. Della Porta,Pierre Fenaux,Norbert Gattermann,Ulrich Germing,Joop H. Jansen,Moshe Mittelman,Ghulam J. Mufti,Uwe Platzbecker,Guillermo Sanz,Dominik Selleslag,Mette Skov-Holm,Reinhard Stauder,Argiris Symeonidis,Arjan A. van de Loosdrecht,Theo de Witte,Mario Cazzola +21 more
TLDR
Within the myelodysplastic syndrome (MDS) work package of the European LeukemiaNet, an Expert Panel was selected according to the framework elements of the National Institutes of Health Consensus Development Program and Guidelines were developed on the basis of a list of patient- and therapy-oriented questions.About:
This article is published in Blood.The article was published on 2013-10-24 and is currently open access. It has received 537 citations till now. The article focuses on the topics: European LeukemiaNet & Evidence-based medicine.read more
Citations
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Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
David P. Steensma,Rafael Bejar,Siddhartha Jaiswal,R. Coleman Lindsley,Mikkael A. Sekeres,Robert P. Hasserjian,Benjamin L. Ebert +6 more
TL;DR: The nature and prevalence of CHIP, distinction of this state from MDS, and current areas of uncertainty regarding diagnostic criteria for myeloid malignancies are discussed.
Journal ArticleDOI
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes
T Haferlach,Yasunobu Nagata,Vera Grossmann,Yusuke Okuno,Ulrike Bacher,Genta Nagae,Susanne Schnittger,Masashi Sanada,Ayana Kon,Tamara Alpermann,Kenichi Yoshida,Andreas Roller,Niroshan Nadarajah,Yuichi Shiraishi,Yusuke Shiozawa,Kenichi Chiba,Hirokazu Tanaka,H P Koeffler,Hans-Ulrich Klein,Martin Dugas,Hiroyuki Aburatani,Alexander Kohlmann,Satoru Miyano,Claudia Haferlach,Wolfgang Kern,Seishi Ogawa +25 more
TL;DR: Large-scale genetic and molecular profiling of multiple target genes is invaluable for subclassification and prognostication in MDS patients.
Journal ArticleDOI
Landscape Of Genetic Lesions In 944 Patients With Myelodysplastic Syndromes
Yasunobu Nagata,Vera Grossmann,Yusuke Okuno,Ulrike Bacher,Genta Nagae,Susanne Schnittger,Yusuke Shiozawa,Ayana Kon,Tamara Alpermann,Kenichi Yoshida,Masashi Sanada,Andreas Roller,Niroshan Nadarajah,Yuichi Shiraishi,H. Phillip Koeffler,Hans-Ulrich Klein,Martin Dugas,Kenichi Chiba,Hiroko Tanaka,Alexander Kohlmann,Satoru Miyano,Claudia Haferlach,Hiroyuki Aburatani,Wolfgang Kern,Seishi Ogawa,Torsten Haferlach +25 more
TL;DR: These results demonstrated that the mutation/deletion status of a set of genes could be used as variables independent of clinical parameters to build a clinically relevant prognostic score.
Journal ArticleDOI
Clinical significance of somatic mutation in unexplained blood cytopenia
Luca Malcovati,Anna Gallì,Erica Travaglino,Ilaria Ambaglio,Ettore Rizzo,Elisabetta Molteni,Chiara Elena,Virginia Valeria Ferretti,Silvia Catricalà,Elisa Bono,Gabriele Todisco,Antonio Bianchessi,Elisa Rumi,Silvia Zibellini,Daniela Pietra,Emanuela Boveri,Clara Camaschella,Daniela Toniolo,Elli Papaemmanuil,Seishi Ogawa,Mario Cazzola +20 more
TL;DR: Mutation analysis on peripheral blood granulocytes may significantly improve the current diagnostic approach to unexplained cytopenia and more generally the diagnostic accuracy of myeloid neoplasms.
Journal ArticleDOI
SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts.
Luca Malcovati,Mohsen Karimi,Elli Papaemmanuil,Ilaria Ambaglio,Martin Jädersten,Monika Jansson,Chiara Elena,Anna Gallì,Gunilla Walldin,Matteo G. Della Porta,Klas Raaschou-Jensen,Erica Travaglino,Klaus Kallenbach,Daniela Pietra,Viktor Ljungström,Simona Conte,Emanuela Boveri,Rosangela Invernizzi,Richard Rosenquist,Peter J. Campbell,Mario Cazzola,Eva Hellstrom Lindberg +21 more
TL;DR: SF3B1 mutation identifies a distinct MDS subtype that is unlikely to develop detrimental subclonal mutations and is characterized by indolent clinical course and favorable outcome.
References
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WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
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Toxicity and response criteria of the Eastern Cooperative Oncology Group
Martin M. Oken,Richard H. Creech,Douglass C. Tormey,John Horton,Thomas E. Davis,Eleanor T. McFadden,Paul P. Carbone +6 more
TL;DR: The Eastern Cooperative Oncology Group criteria for toxicity and response are presented to facilitate future reference and to encourage further standardization among those conducting clinical trials.
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An international system for human cytogenetic nomenclature
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The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
James W. Vardiman,Juergen Thiele,Daniel A. Arber,Richard D. Brunning,Michael J. Borowitz,Anna Porwit,Nancy L. Harris,Michelle M. Le Beau,Eva Hellström-Lindberg,Ayalew Tefferi,Clara D. Bloomfield +10 more
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International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes
Peter L. Greenberg,Christopher Cox,Michelle M. LeBeau,Pierre Fenaux,Pierre Morel,Guillermo Sanz,Miguel A. Sanz,Teresa Vallespi,Terry J. Hamblin,David Oscier,Kazuma Ohyashiki,Keisuke Toyama,Carlo Aul,Ghulam J. Mufti,John M. Bennett +14 more
TL;DR: The International MDS Risk Analysis Workshop combined cytogenetic, morphological, and clinical data from seven large previously reported risk-based studies that had generated prognostic systems as discussed by the authors.
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Revised International Prognostic Scoring System for Myelodysplastic Syndromes
Peter L. Greenberg,Heinz Tuechler,Julie Schanz,Guillermo Sanz,Guillermo Garcia-Manero,Francesc Solé,John M. Bennett,David T. Bowen,Pierre Fenaux,François Dreyfus,Hagop M. Kantarjian,Andrea Kuendgen,Alessandro Levis,Luca Malcovati,Mario Cazzola,Jaroslav Cermak,Christa Fonatsch,Michelle M. Le Beau,Marilyn L. Slovak,Otto Krieger,Michael Luebbert,Jaroslaw P. Maciejewski,Silvia Maria Meira Magalhães,Yasushi Miyazaki,Michael Pfeilstöcker,Mikkael A. Sekeres,Wolfgang R. Sperr,Reinhard Stauder,Sudhir Tauro,Peter Valent,Teresa Vallespi,Arjan A. van de Loosdrecht,Ulrich Germing,Detlef Haase +33 more
Clinical and biological implications of driver mutations in myelodysplastic syndromes.
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