Properdin binds to sulfatide [Gal(3-SO4)beta 1-1 Cer] and has a sequence homology with other proteins that bind sulfated glycoconjugates.
TLDR
Data suggest that properdin, like antistasin and thrombospondin, binds sulfated glycoconjugates and supports the conclusion that the homologous sequences are sulfated glycolipids, gangliosides, and phospholipids.About:
This article is published in Journal of Biological Chemistry.The article was published on 1990-02-15 and is currently open access. It has received 132 citations till now. The article focuses on the topics: Properdin & Alternative complement pathway.read more
Citations
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Connective tissue growth factor : a mediator of tgf-beta action on fibroblasts
TL;DR: Because the biological actions of TGF-β are complex and affect many different cell types, CTGF may serve as a more specific target for selective intervention in processes involving connective tissue formation during wound repair or fibrotic disorders.
Journal ArticleDOI
The CCN family of angiogenic regulators: the integrin connection.
Lester F. Lau,Stephen C.-T. Lam +1 more
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The modular architecture of a new family of growth regulators related to connective tissue growth factor
TL;DR: In this article, the authors characterized and sequenced members of a new family of growth regulators (originally called cef10, connective tissue growth factor, fisp-12, cyr61, or, alternatively, βIG-M1 and βG-M2), all of which belong to immediate-early genes expressed after induction by growth factors or certain oncogenes.
Journal ArticleDOI
WISP genes are members of the connective tissue growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors
Diane Pennica,Todd A. Swanson,James W. Welsh,Margaret Ann Roy,David A. Lawrence,James Lee,Jennifer Brush,Lisa A. Taneyhill,Bethanne Deuel,Michael Lew,Colin K. Watanabe,Robert L. Cohen,Mona F. Melhem,Gene Grant Finley,Phil Quirke,Audrey Goddard,Kenneth J. Hillan,Austin L. Gurney,David Botstein,David Botstein,Arnold J. Levine +20 more
TL;DR: The identification of two genes, WISP-1 and W ISP-2, that are up-regulated in the mouse mammary epithelial cell line C57MG transformed by Wnt-1, but not by Wnnt-4 are reported, suggesting that the WISp genes may be downstream of WNT-1 signaling and that aberrant levels of WISPs expression in colon cancer may play a role in colon tumorigenesis.
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The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.
TL;DR: This work focuses on the regulation of Cellular Functions by the CCN Family and the structure of the Connective Tissue Growth Factor/Cysteine-Rich 61/Nephroblastoma Overexpressed family members.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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Molecular Organization and Function of the Complement System
TL;DR: The purpose of this presentation is to provide a chronology of events leading up to and including the creation of the C3 Convertase, as well as some of the key players in the development of the Convertase.
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Isolation and characterization of antistasin. An inhibitor of metastasis and coagulation.
TL;DR: The purpose of this study was to purify and characterize the agent responsible for the antimetastatic activity of an extract of the salivary glands of the Mexican leech Haementeria officinalis, and it was discovered that heparin affinity chromatography followed by anion-exchange chromatography results in a fraction highly enriched in both potent anticoagulant activity and potent antimetASTatic activity.
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The platelet glycoprotein thrombospondin binds specifically to sulfated glycolipids.
David D. Roberts,Doris M. Haverstick,Vishva M. Dixit,William A. Frazier,Samuel A. Santoro,Victor Ginsburg +5 more
TL;DR: Binding of 125I-TSP to lipids from sheep and human erythrocytes and human platelets resolved on thin layer chromatograms indicates that sulfatides are the only lipids in the membrane which bind TSP.
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Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement.
TL;DR: It is concluded that isolated human properdin is polydisperse and consists of a set of cyclic polymers constructed from a single highly asymmetric and flexible protomer.
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The modular architecture of a new family of growth regulators related to connective tissue growth factor
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