Protein and Glycan Mimicry in HIV Vaccine Design.
TLDR
It is argued that recombinant mimics of the envelope spike are currently capable of capturing many features of the native viral glycan shield, and strategies through which the immunogenicity of Env glycans may be enhanced in the development of future immunogens are explored.About:
This article is published in Journal of Molecular Biology.The article was published on 2019-05-31 and is currently open access. It has received 96 citations till now. The article focuses on the topics: Viral membrane & Glycan.read more
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The annual meeting of the federation of american societies for experimental biology
TL;DR: A new peer-reviewed, open access journal, FASEB BioAdvances, launching in 2018 as part of the Wiley Open Access portfolio will be edited by Jasna Markovac, Ph.D., of the University of Michigan and California Inst itute of Technology.
References
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Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
Supachai Rerks-Ngarm,Punnee Pitisuttithum,Sorachai Nitayaphan,Jaranit Kaewkungwal,Joseph Chiu,Robert Paris,Nakorn Premsri,Chawetsan Namwat,Mark de Souza,Elizabeth Adams,Michael Benenson,Sanjay Gurunathan,Jim Tartaglia,John G. McNeil,Donald P. Francis,Donald Stablein,Deborah L. Birx,Supamit Chunsuttiwat,Chirasak Khamboonruang,Prasert Thongcharoen,Merlin L. Robb,Nelson L. Michael,Prayura Kunasol,Jerome H. Kim +23 more
TL;DR: This ALVAC-HIV and AIDSVAX B/E vaccine regimen may reduce the risk of HIV infection in a community-based population with largely heterosexual risk and offer insight for future research.
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Antibody neutralization and escape by HIV-1
Xiping Wei,Julie M. Decker,Shuyi Wang,Huxiong Hui,John C. Kappes,Xiaoyun Wu,Jesus F. Salazar-Gonzalez,Maria G. Salazar,J. Michael Kilby,Michael S. Saag,Natalia L. Komarova,Martin A. Nowak,Beatrice H. Hahn,Peter D. Kwong,George M. Shaw +14 more
TL;DR: The detection of autologous Nab as early as 52 days after detection of HIV-specific antibodies is reported, indicating a new mechanism contributing to HIV-1 persistence in the face of an evolving antibody repertoire.
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