Open AccessJournal Article
Protein phosphorylation sites regulate the function of the bipartite NLS of nucleolin.
M S Schwab,C Dreyer +1 more
TLDR
Fusion proteins consisting of maltose binding protein (MBP) and nucleolin are constructed and nuclear targetting of MBP by the bipartite nuclear localization signal of nucleolin became significantly more efficient after addition of either CK2 sites or cdc2 sites to the MBP-NLS construct.About:
This article is published in European Journal of Cell Biology.The article was published on 1997-08-01 and is currently open access. It has received 71 citations till now. The article focuses on the topics: Nucleolin & Nuclear localization sequence.read more
Citations
More filters
Journal ArticleDOI
Structure and functions of nucleolin
TL;DR: The involvement of nucleolin at multiple steps of this biosynthetic pathway suggests that it could play a key role in this highly integrated process of ribosome biogenesis.
Journal ArticleDOI
Molecular dissection of nucleolin’s role in growth and cell proliferation: new insights
TL;DR: Nucleolin is a major nucleolar protein of exponentially growing eukaryotic cells, which is directly involved in the regulation of ribosome biogenesis and maturation, and is a target for regulation by proteolysis, methylation, ADP‐ribosylation, and phosphorylation by CKII, cdc2, PKC‐ξ, cyclic AMP‐dependent protein kinase, and ecto‐protein kinase.
Journal ArticleDOI
Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels
Sven Christian,Jan Pilch,Maria E. Åkerman,Maria E. Åkerman,Kimmo Porkka,Kimmo Porkka,Pirjo Laakkonen,Erkki Ruoslahti +7 more
TL;DR: Results show that cell surface nucleolin is a specific marker of angiogenic endothelial cells within the vasculature and may be a useful target molecule for diagnostic tests and drug delivery applications.
Journal ArticleDOI
Antiproliferative Activity of G-rich Oligonucleotides Correlates with Protein Binding *
TL;DR: A series of guanosine-rich phosphodiester oligodeoxynucleotides that strongly inhibit proliferation in a number of human tumor cell lines are described and represent a new class of potentially therapeutic agents with a novel mechanism of action.
Journal ArticleDOI
RNA-binding protein nucleolin in disease
Kotb Abdelmohsen,Myriam Gorospe +1 more
TL;DR: The RNA-binding activities of nucleolin are reviewed, its influence on gene expression patterns, and its impact upon diseases are reviewed.