Journal ArticleDOI
Prothrombotic state in glioblastoma multiforme: an evaluation of the procoagulant activity of circulating microparticles.
Maria Teresa Sartori,Alessandro Della Puppa,Andrea Ballin,Graziella Saggiorato,Daniela Bernardi,Andrea Padoan,Renato Scienza,Domenico D'Avella,Giuseppe Cella +8 more
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TLDR
GBM patients may have an increase in MP-associated procoagulant activity that could contribute to any prothrombotic states and increases the likelihood of VTE complications; this procoagellant activity drops during control of disease.Abstract:
The relationship between venous thromboembolism (VTE) and cancer is supported by several pathogenetic factors, including circulating microparticles (MP) originating from different cells and often bearing tissue factor. Since VTE often complicates the clinical course of patients with glioblastoma multiforme (GBM; WHO grade IV astrocytoma) and the role of MPs in these patients population is still not clear, this prospective study was conducted to evaluate the procoagulant activity of circulating MP (MP activity) in GBM patients. We enrolled 61 GBM patients undergoing gross-total or subtotal surgical resection followed by combined radio-chemotherapy; 20 healthy volunteers were tested as controls. Blood samples for MP activity and hemostatic profiles were obtained before and then 1 week and 1, 4, and 7 months after surgery. GBM patients had significantly higher mean MP activity levels than healthy controls before and 7 days after surgery. During the follow-up, MP activity levels became significantly lower 1 and 4 months after surgery (P = 0.007 and P = 0.018, respectively) than prior to surgery, but this decrease was only seen in the subgroup achieving complete tumor resection. MP activity levels increased in 7 (63.6%) of 11 patients who developed VTE. The different incidence of the increase in MP activity levels between patients with and without VTE was statistically significant (χ2 = 4.93, P = 0.026; relative risk 1.38, 95% CI 1.03–1.86). GBM patients may have an increase in MP-associated procoagulant activity that could contribute to any prothrombotic states and increases the likelihood of VTE complications; this procoagulant activity drops during control of disease.read more
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Journal ArticleDOI
Microparticles in Hemostasis and Thrombosis
A. Phillip Owens,Nigel Mackman +1 more
TL;DR: In cancer, PS+, TF+ MPs are derived from tumors and may serve as a useful biomarker to identify patients at risk for venous thrombosis and this review will summarize the current knowledge of the role of procoagulant MPs in hemostasis and thromBosis.
Journal ArticleDOI
Tumor-derived tissue factor–positive microparticles and venous thrombosis in cancer patients
Julia E. Geddings,Nigel Mackman +1 more
TL;DR: Results suggest that TF-positive MPs may be a useful biomarker to identify patients with cancer who are at high risk for thrombosis.
Journal ArticleDOI
Extracellular vesicles - biomarkers and effectors of the cellular interactome in cancer.
TL;DR: Embracing the notion that human cancers are defined not only by processes occurring within cancer cells, but also between them, and amidst the altered tumor and systemic microenvironment may open new diagnostic and therapeutic opportunities.
Journal ArticleDOI
Extracellular vesicles and intercellular communication within the nervous system
Valentina Zappulli,Kristina Pagh Friis,Zachary Fitzpatrick,Casey A. Maguire,Xandra O. Breakefield +4 more
TL;DR: The current understanding of EVs is described and serves as a springboard for future advances, which may reveal new important mechanisms by which EVs in coordinate brain and body function and dysfunction.
Journal ArticleDOI
Mechanistic View of Risk Factors for Venous Thromboembolism
TL;DR: A narrative review of known common risk factors for venous thromboembolism within an extended version of Virchow's triad is discussed.
References
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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
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Derivation of a Simple Clinical Model to Categorize Patients Probability of Pulmonary Embolism: Increasing the Models Utility with the SimpliRED D-dimer
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Philip S. Wells,David Anderson,Janis Bormanis,Fred Guy,Michael Mitchell,Lisa Gray,Cathy Clement,K Sue Robinson,Bernard Lewandowski +8 more
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