Quantitative assessment of CA1 local circuits: Knowledge base for interneuron-pyramidal cell connectivity
Marianne Bezaire,Ivan Soltesz +1 more
TLDR
A current, quantitative estimate of the cellular and synaptic constituents of the CA1 region of the rat hippocampus is provided and the quantitative knowledge base assembled and synthesized here forms the basis for data‐driven, large‐scale computational modeling efforts.Abstract:
In this work, through a detailed literature review, data-mining, and extensive calculations, we provide a current, quantitative estimate of the cellular and synaptic constituents of the CA1 region of the rat hippocampus. Beyond estimating the cell numbers of GABAergic interneuron types, we calculate their convergence onto CA1 pyramidal cells and compare it with the known input synapses on CA1 pyramidal cells. The convergence calculation and comparison are also made for excitatory inputs to CA1 pyramidal cells. In addition, we provide a summary of the excitatory and inhibitory convergence onto interneurons. The quantitative knowledge base assembled and synthesized here forms the basis for data-driven, large-scale computational modeling efforts. Additionally, this work highlights specific instances where the available data are incomplete, which should inspire targeted experimental projects towards a more complete quantification of the CA1 neurons and their connectivity.read more
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Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning
TL;DR: Alteration of the physiological mechanisms supporting SPW‐Rs leads to their pathological conversion, “p‐ripples,” which are a marker of epileptogenic tissue and can be observed in rodent models of schizophrenia and Alzheimer's Disease.
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Fast-spiking, parvalbumin+ GABAergic interneurons: From cellular design to microcircuit function
Hua Hu,Jian Gan,Peter Jonas +2 more
TL;DR: Not only are PV+ interneurons involved in basic microcircuit functions, but they also play a role in complex network operations, including expansion of dynamic activity range, pattern separation, modulation of place and grid field shapes, phase precession, and gain modulation of sensory responses.
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Hippocampal GABAergic Inhibitory Interneurons.
Kenneth A. Pelkey,Ramesh Chittajallu,Michael T. Craig,Ludovic Tricoire,Ludovic Tricoire,Jason C. Wester,Jason C. Wester,Chris J. McBain,Chris J. McBain +8 more
TL;DR: An overview of the current state of the field of interneuron research, focusing largely on the hippocampus, discusses recent advances related to the various cell types, including their development and maturation, expression of subtype-specific voltage- and ligand-gated channels, and their roles in network oscillations.
Journal ArticleDOI
Parvalbumin-Positive Basket Cells Differentiate among Hippocampal Pyramidal Cells
Sang-Hun Lee,Ivan Marchionni,Marianne Bezaire,Csaba Varga,Nathan Danielson,Matthew Lovett-Barron,Attila Losonczy,Ivan Soltesz +7 more
TL;DR: It is found that parvalbumin-expressing basket cells (PVBCs) evoked greater inhibition in CA1 PCs located in the deep compared to superficial layer of stratum pyramidale, demonstrating bias in target selection by both the excitatory and inhibitory local connections inCA1.
Journal ArticleDOI
Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics
Yoav Adam,Jeong J. Kim,Shan Lou,Yongxin Zhao,Michael E. Xie,Daan Brinks,Hao Wu,Mohammed A. Mostajo-Radji,Simon Kheifets,Vicente Parot,Selmaan N. Chettih,Katherine J. Williams,Benjamin Gmeiner,Samouil L. Farhi,Linda Madisen,E. Kelly Buchanan,Ian Kinsella,Ding Zhou,Liam Paninski,Christopher D. Harvey,Hongkui Zeng,Paola Arlotta,Robert E. Campbell,Adam E. Cohen,Adam E. Cohen +24 more
TL;DR: Improved near-infrared voltage indicators, high-speed microscopes and targeted gene expression schemes enabled simultaneous in vivo optogenetic control and recording of voltage dynamics in multiple neurons in the hippocampus of behaving mice.
References
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TL;DR: A stereological method for obtaining estimates of the total number of neurons in five major subdivisions of the rat hippocampus is described, and a number of new stereological methods that have particular relevance to the quantitative study of the structure of the nervous system are briefly described in an appendix.
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Big Data: A Revolution That Will Transform How We Live, Work, and Think
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