Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells (Proceedings of the National Academy of Sciences of the United States of America (2014) 111 (E2182-E2190) DOI: 10.1073/pnas.1404943111)
Tingfang Yi,Bo Zhai,Yonghao Yu,Yoshikawa Kiyotsugu,Thomas Raschle,Manuel Etzkorn,Hee Chan Seo,Michal J. Nagiec,Rafael E. Luna,Ellis L. Reinherz,John Blenis,Steven P. Gygi,Gerhard Wagner +12 more
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This article is published in Proceedings of the National Academy of Sciences of the United States of America.The article was published on 2014-01-01 and is currently open access. It has received 6 citations till now.read more
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Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple ‘Omic’ Layers
TL;DR: A trans-ome-wide association study connecting phenotypes with trans-omic networks that reflect both genetic and environmental factors, which can characterize several complex lifestyle diseases as breakdowns in the trans-omics system are proposed.
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The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways
Tilman Borggrefe,Matthias Lauth,An Zwijsen,Danny Huylebroeck,Franz Oswald,Benedetto Daniele Giaimo +5 more
TL;DR: The intracellular post-translational regulation of Notch that fine-tunes the outcome of the Notch response is reviewed and how crosstalk with other conserved signaling pathways like the Wnt, Hedgehog, hypoxia and TGFβ/BMP pathways can affect Notch signaling output is described.
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Mithramycin A sensitizes therapy-resistant breast cancer stem cells toward genotoxic drug doxorubicin.
Shilpi Saha,Shravanti Mukherjee,Minakshi Mazumdar,Argha Manna,Poulami Khan,Arghya Adhikary,Kirti Kajal,Debarshi Jana,Gaurisankar Sa,Sanhita Mukherjee,Diptendra K. Sarkar,Tanya Das +11 more
TL;DR: It is reported that mithramycin A, a known specificity protein (Sp)1 inhibitor, sensitizes breast CSCs (bCSCs) by perturbing the expression of drug efflux transporters, ATP-binding cassette sub-family G, member 2 (ABCG2) and ABCC1, which are inherently upregulated in these cells compared with the rest of the tumor population.
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Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer.
Qin Tian,Ping Yuan,Chuntao Quan,Mingyang Li,Juanjuan Xiao,Juanjuan Xiao,Lu Zhang,Hui Lu,Tengfei Ma,Ling Zou,Fei Wang,Peipei Xue,Xiaofang Ni,Wei Wang,Lin Liu,Zhe Wang,Feng Zhu,Feng Zhu,Qiuhong Duan +18 more
TL;DR: The identification of BCKDK as a novel prometastatic factor in human CRC will be beneficial for further diagnostic biomarker studies and suggests novel targeting opportunities.
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Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells.
TL;DR: Some transcription factors such as Nanog, NF-κB, and Bmi-1 that cooperate with CXCR4/CXCL12 for the maintenance of stemness and induction of metastasis behavior in cancer stem cells are focused on.