Journal ArticleDOI
Quantitative spatial distribution of sirolimus and polymers in drug-eluting stents using confocal Raman microscopy.
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TLDR
Three separate calibration curves were developed to describe the solid phase distribution found on drug-polymer coated stents using Raman spectroscopy to differentiate each component found in the CYPHER Sirolimus-eluting Coronary Stent.Abstract:
Raman spectroscopy was used to differentiate each component found in the CYPHER Sirolimus-eluting Coronary Stent The unique spectral features identified for each component were then used to develop three separate calibration curves to describe the solid phase distribution found on drug-polymer coated stents The calibration curves were obtained by analyzing confocal Raman spectral depth profiles from a set of 16 unique formulations of drug-polymer coatings sprayed onto stents and planar substrates The sirolimus model was linear from 0 to 100 wt % of drug The individual polymer calibration curves for poly(ethylene-co-vinyl acetate) [PEVA] and poly(n-butyl methacrylate) [PBMA] were also linear from 0 to 100 wt % The calibration curves were tested on three independent drug-polymer coated stents The sirolimus calibration predicted the drug content within 1 wt % of the laboratory assay value The polymer calibrations predicted the content within 7 wt % of the formulation solution content Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectra from five formulations confirmed a linear response to changes in sirolimus and polymer contentread more
Citations
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Patent
Drug delivery medical device
TL;DR: In this article, the authors present a scenario where a medical device is deployed at an intervention site inside the body of a subject and a portion of the injected pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a part of the implantable device along with other carrying agents.
Journal ArticleDOI
Stent elution rate determines drug deposition and receptor-mediated effects
TL;DR: Model predictions that tissue content linearly tracks stent elution rate were validated in porcine coronary artery sirolimus-eluting stents implants and receptor saturating drug doses are predicted to be most efficacious when eluted from stents in a constant zero order fashion as this maximizes the duration of elution and receptor saturation.
Journal ArticleDOI
Raman imaging of drug delivery systems
TL;DR: This review article includes an introduction to the principals of Raman spectroscopy, an outline of the experimental systems used for Raman imaging and the associated important considerations and limitations of this method, along with summary tables of the literature at this point in time.
Journal ArticleDOI
Preparation and properties of thin parylene layers as the gate dielectrics for organic field effect transistors
TL;DR: The results demonstrated that using parylene, as the gate dielectric layer is an effective method to fabricate OFETs with improved electric characteristics.
Journal ArticleDOI
Detection of counterfeit Viagra by Raman microspectroscopy imaging and multivariate analysis
Pierre-Yves Sacre,Eric Deconinck,L. Saerens,Thomas De Beer,Patricia Courselle,Roy Vancauwenberghe,Patrice Chiap,Jacques Crommen,Jacques O. De Beer +8 more
TL;DR: PCA was applied as exploratory analysis tool on different spectral ranges to detect counterfeit medicines based on the full spectra, the presence of lactose and the spatial distribution of sildenafil inside the tablet.
References
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Book
Infrared and Raman Characteristic Group Frequencies: Tables and Charts
TL;DR: This new edition of this highly successful manual is not only a revised text but has been extended to meet the interpretive needs of Raman users as well as those working in the IR region, creating a uniquely practical, comprehensive and detailed source for spectral interpretation.
Journal ArticleDOI
Stent-Based Delivery of Sirolimus Reduces Neointimal Formation in a Porcine Coronary Model
Takeshi Suzuki,Greg Kopia,Shin Ichiro Hayashi,Lynn Bailey,Gerard H. Llanos,Robert L. Wilensky,Bruce D. Klugherz,George Papandreou,Pallassana Narayan,Martin B. Leon,Alan C. Yeung,Fermin O. Tio,Philip S. Tsao,Robert Falotico,Andrew J. Carter +14 more
TL;DR: Stent-based delivery of SRL via a nonerodable polymer matrix is feasible and effectively reduces in-stent neointimal hyperplasia by inhibiting cellular proliferation.
Journal ArticleDOI
Bioactive coatings of endovascular stents based on polyelectrolyte multilayers.
TL;DR: The enhanced thromboresistance of the self-assembled multilayer together with the antiinflammatory and wound healing properties of hyaluronan and chitosan are expected to reduce the neointimal hyperplasia associated with stent implantation.
Journal ArticleDOI
Mechanisms of controlled drug release from drug-eluting stents.
Ghanashyam Acharya,Kinam Park +1 more
TL;DR: The clinical importance of drug-eluting stents has been demonstrated by their unparalleled success in preventing restenosis after stenting procedures, and it is imperative to understand the drug delivery mechanisms and the approaches available for drug coating on the stents.
Journal ArticleDOI
Analysis of a phosphorylcholine-based polymer coating on a coronary stent pre- and post-implantation
TL;DR: Both the long-term stability and relative biological inertness of the coating has been confirmed in vivo, supporting its use as a vehicle for local drug delivery.