Journal ArticleDOI
Radiosurgery for intracranial meningiomas: A systematic review and meta-analysis
Valentina Pinzi,Elena Biagioli,Anna Roberto,Francesca Galli,Michele Rizzi,Federica Chiappa,Greta Brenna,Laura Fariselli,Irene Floriani +8 more
TLDR
Efforts are needed in standardizing the definition of local and symptom control and toxicity in order to properly compare different treatment schedules and RS can be considered a safe and effective treatment.Abstract:
Background Radiosurgery(RS), both in single and multiple sessions, have been performed for intracranial meningiomas. Different aspects are still controversial on this field. The aim of this systematic review is to summarize the current literature on long-term efficacy and safety of RS for meningiomas. Methods Online databases were searched for studies published until April 2015. The primary outcomes were disease control and progression-free-survival(PFS). The secondary outcomes were symptom control and radiation-induced toxicity. Results The estimate of disease control rate ranged from 87.0% to 100.0% at 5 years and from 67.0% to 100.0% at 10 years. The PFS rate ranged 78.0%–98.9% and 53.1%–97.2% at 5 and 10 years, respectively. The overall symptom control was 92.3%, the overall toxicity was 8.1%. Conclusions RS can be considered a safe and effective treatment. Efforts are needed in standardizing the definition of local and symptom control and toxicity in order to properly compare different treatment schedules.read more
Citations
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Journal ArticleDOI
Long-Term Clinical Outcomes of Pencil Beam Scanning Proton Therapy for Benign and Non-benign Intracranial Meningiomas.
Fritz R Murray,James W. Snider,Alessandra Bolsi,Antony J. Lomax,M. Walser,Ulrike Kliebsch,Ralf Schneider,Damien C. Weber +7 more
TL;DR: Pencil beam scanning proton therapy is an effective and safe treatment for patients with intracranial meningiomas, resulting in high local control rates with limited toxicity, and up-front radiation likely results in improved outcomes.
Journal ArticleDOI
Contemporary Management of Meningiomas with Radiosurgery
Demiral Selcuk,Dincoglan Ferrat,Sager Omer,Uysal Bora,Gamsiz Hakan,Ozcan Fatih,Dirican Bahar,Beyzadeoglu Murat +7 more
TL;DR: Demiral et al. as mentioned in this paper described the contemporary management of Meningiomas with radiosurgery. But their work focused on the management of radiolabels, and not on the treatment of the MRIs.
Journal ArticleDOI
ESTRO ACROP guideline for target volume delineation of skull base tumors
Stephanie E. Combs,Brigitta G. Baumert,Martin Bendszus,Alessandro Bozzao,Michael Brada,Laura Fariselli,Alba Fiorentino,Ute Ganswindt,Anca L. Grosu,Frank L Lagerwaard,Maximilian Niyazi,Tufve Nyholm,Ian Paddick,Damien C. Weber,Claus Belka,Giuseppe Minniti +15 more
TL;DR: This ESTRO ACROP guideline achieved detailed recommendations on target volume definition for skull base tumors, as well as comprehensive advice about imaging modalities and radiation techniques.
Journal ArticleDOI
Intraventricular meningiomas frequently harbor NF2 mutations but lack common genetic alterations in TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT.
Gerhard Jungwirth,Rolf Warta,Christopher Beynon,Felix Sahm,Felix Sahm,Andreas von Deimling,Andreas von Deimling,Andreas Unterberg,Christel Herold-Mende,Christine Jungk +9 more
TL;DR: Interestingly, all WHO°II IVMs (n = 3) harbored SMARCB1 and SMARCA4 mutations, indicating a role of the SWI/SNF chromatin remodeling complex in aggressive IVMs.
Journal ArticleDOI
Multisession radiosurgery for perioptic meningiomas: medium-to-long term results from a CyberKnife cooperative study
Marcello Marchetti,Alfredo Conti,Alfredo Conti,Giancarlo Beltramo,Valentina Pinzi,Antonio Pontoriero,Irene Tramacere,Carolin Senger,Stefano Pergolizzi,Laura Fariselli +9 more
TL;DR: 25 Gy delivered in 5 fractions is an effective modality for meningiomas that are near the AOP or are too large to be treated by sRS, and controlled the tumors while sparing visual function.
References
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