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Raising high-density lipoprotein cholesterol with inhibitors of cholesteryl ester transfer protein - a new approach to coronary
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The article was published on 2004-01-01 and is currently open access. It has received 0 citations till now. The article focuses on the topics: Cholesterylester transfer protein & Very low-density lipoprotein.read more
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Journal ArticleDOI
Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol
Hanna Bloomfield Rubins,Sander J. Robins,Dorothea Collins,Carol L. Fye,James W. Anderson,Marshall B. Elam,Fred H. Faas,Esteban Linares,Ernst J. Schaefer,Gordon Schectman,Timothy J Wilt,Janet Wittes +11 more
TL;DR: Gemfibrozil therapy resulted in a significant reduction in the risk of major cardiovascular events in patients with coronary disease whose primary lipid abnormality was a low HDL cholesterol level, suggesting that the rate of coronary events is reduced by raising HDL cholesterol levels and lowering levels of triglycerides without lowering LDL cholesterol levels.
Journal ArticleDOI
Cholesteryl Ester Transfer Protein: A Novel Target for Raising HDL and Inhibiting Atherosclerosis
Philip J. Barter,H. Bryan Brewer,M. John Chapman,Charles H. Hennekens,Daniel J. Rader,Alan R. Tall +5 more
TL;DR: Small-molecule inhibitors of CETP have now been tested in human subjects and shown to increase the concentration of HDL cholesterol while decreasing that of LDL cholesterol and apoB, and test the hypothesis in randomized trials of humans that pharmacological inhibition of CETp retards the development of atherosclerosis.
Journal ArticleDOI
A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits
Hiroshi Okamoto,Fumihiko Yonemori,Korekiyo Wakitani,Takashi Minowa,Kimiya Maeda,Hisashi Shinkai +5 more
TL;DR: CETP inhibitors that form a disulphide bond with CETP are described and one such inhibitor is presented that increases HDL cholesterol, decreases non-HDL cholesterol and inhibits the progression of atherosclerosis in rabbits.
Journal ArticleDOI
Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study
Greetje J. de Grooth,Jan Albert Kuivenhoven,Anton F. H. Stalenhoef,Jacqueline de Graaf,Aeilko H. Zwinderman,J. L. Posma,Arie van Tol,John J.P. Kastelein +7 more
TL;DR: The use of the CETP inhibitor JTT-705 in humans is an effective means to raise HDL cholesterol levels with minor gastrointestinal side effects, and further studies are needed to investigate whether the observed increase in HDL cholesterol translates into a concomitant reduction in coronary artery disease risk.
Journal ArticleDOI
Prevalence of risk factors in men with premature coronary artery disease.
Jacques Genest,Jacques Genest,Judith R. McNamara,Judith R. McNamara,Deeb N. Salem,Deeb N. Salem,Ernst J. Schaefer,Ernst J. Schaefer +7 more
TL;DR: The prevalence of modifiable cardiovascular risk factors was markedly higher in the patients with CAD than in Framingham Offspring Study subjects, whereas the prevalence of LDL cholesterol greater than or equal to 160 mg/dl was not significantly different between Patients with CAD and Framinghamoffspring Study subjects.
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