Randomized, double-blind trial of chitosan for body weight reduction
TLDR
The above data suggest that chitosan in the administered dosage, without dietary alterations, does not reduce body weight in overweight subjects, and is not incorporated as a major constituent into several over-the-counter remedies.Abstract:
Background: Overweight and obesity is a prevalent and costly threat to public health. Compelling evidence links overweight and obesity with serious disorders such as cardiovascular diseases and diabetes. Dietary regimen are notoriously burdened with poor compliance. Chitosan is promoted in the US and other countries as an oral remedy to reduce fat absorption and has now been incorporated as a major constituent into several over-the-counter remedies. The primary aim of this study is to investigate the clinical effectiveness of oral chitosan for body weight reduction. Methods: Thirty-four overweight volunteers were included in a randomized placebo-controlled double-blind trial. Subjects were assigned to receive either four capsules of chitosan or indistinguishable placebo twice daily for 28 consecutive days. Measurements were taken at baseline, after 14 and 28 d of treatment. Subjects maintained their normal diet and documented the type and amount of food consumed. Adverse effects were assessed and compliance monitored. Results: Data from 30 subjects were entered into an intention-to-treat analysis. After four weeks of treatment, body mass index, serum cholesterol, triglycerides, vitamin A, D, E and β-carotene were not significantly different in subjects receiving chitosan compared to those receiving placebo. Vitamin K was significantly increased after four weeks in the chitosan group compared with placebo (P<0.05). Compliance was 91.5% and 96.0% for chitosan and placebo groups respectively. Conclusion: The above data suggest that chitosan in the administered dosage, without dietary alterations, does not reduce body weight in overweight subjects. No serious adverse effects were reported. Sponsorship: Marshtech Ltd, London.read more
Citations
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Journal ArticleDOI
Chitosan chemistry and pharmaceutical perspectives.
TL;DR: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. S. Nagar, Punjab-160 062, India, Institute of Biochemistry, Faculty of Medicine, Polytechnic University, Via Ranieri 67, IT-60100 Ancona, Italy, and Department of Medicinal Chemistry & Natural Products,The Hebrew University of Jerusalem, School of Pharmacy-Faculty of medicine, Jerusalem 91120, Israel.
Journal ArticleDOI
2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]
David C.W. Lau,James D. Douketis,Katherine M. Morrison,Irene M. Hramiak,Arya M. Sharma,Ehud Ur +5 more
TL;DR: Over the last 20 years, obesity has become the most prevalent nutritional problem in the world, eclipsing undernutrition and infectious disease.
Journal ArticleDOI
Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications.
TL;DR: This review presents the recent research, trends and prospects in chitosan and some special pharmaceutical and biomedical applications are also highlighted.
Journal ArticleDOI
Chitosan: some pharmaceutical and biological aspects--an update.
Anil K. Singla,Manish Chawla +1 more
TL;DR: Chitosan, a natural polysaccharide, is being widely used as a pharmaceutical excipient by the partial deacetylation of chitin, the second most abundant natural polymer.
Journal ArticleDOI
ISSN exercise & sport nutrition review: research & recommendations
Richard B. Kreider,Colin D. Wilborn,Lucas Taylor,Bill Campbell,Anthony L. Almada,Richard L. Collins,Matthew B. Cooke,Conrad P. Earnest,Mike Greenwood,Douglas S. Kalman,Chad M. Kerksick,Susan M. Kleiner,Brian Leutholtz,Hector L. Lopez,Lonnie Lowery,Ron Mendel,Abbie Smith,Marie Spano,Robert Wildman,Darryn S. Willoughby,Tim N. Ziegenfuss,Jose Antonio +21 more
TL;DR: This paper is a five year update of the sports nutrition review article published as the lead paper to launch the JISSN and presents a well-referenced overview of the current state of the science related to how to optimize training and athletic performance through nutrition.
References
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Obesity : Preventing and managing the global epidemic
D. S. Akram,Arne Astrup,T. Atinmo,J. L. Boissin,George A. Bray,K. Carroll,P. Chitson,C. Chunming,William H. Dietz,James O. Hill,Eric Jéquier,C. Komodiki,Yuji Matsuzawa,W. F. Mollentze,K. Moosa,M.I. Noor,K.S. Reddy,Jacob C. Seidell,V. Tanphaichitr,Ricardo Uauy,Paul Zimmet +20 more
Journal ArticleDOI
Overweight and obesity in the United States: prevalence and trends, 1960–1994
TL;DR: Between 1976–80 and 1988–94, the prevalence of obesity (BMI≥30.0) increased markedly in the US, in agreement with trends seen elsewhere in the world.
Journal ArticleDOI
Short form 36 (SF36) health survey questionnaire: normative data for adults of working age.
TL;DR: The SF36 is a potentially valuable tool in medical research and the normative data provided here may further facilitate its validation and use.
Journal ArticleDOI
Economic costs of obesity.
TL;DR: The costs of treatment for severe obesity must be weighed against the improved health status and quality of life, and addition of costs due to musculoskeletal disorders could raise this estimate to 7.8%.
Book
Obesity and Related Diseases
TL;DR: Health implications of obesity definitions and usage measurement of energy stores including Quetelet's index measurement ofenergy intake measurement ofEnergy expenditure aetiology of obesity in man possibilities for the treatment of obesity practical treatment strategies are explored.