Journal ArticleDOI
Rat brain acetylcholinesterase visualized with [11C]physostigmine.
Anna M. Planas,Christian Crouzel,Françoise Hinnen,Antoinette Jobert,Frédéric Né,Luigi Digiamberardino,Bertrand Tavitian +6 more
TLDR
Results indicate that autoradiographic images of the rat brain obtained with [11C]physostigmine reflect AChE distribution, thus supporting the use of this radioligand to trace cerebral A cholinesterase activity in humans with positron emission tomography.About:
This article is published in NeuroImage.The article was published on 1994-06-01. It has received 24 citations till now. The article focuses on the topics: Physostigmine & Acetylcholinesterase.read more
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Journal ArticleDOI
In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors.
Hervé Boutin,Fabien Chauveau,Fabien Chauveau,Cyrille Thominiaux,Bertrand Kuhnast,Marie-Claude Grégoire,Marie-Claude Grégoire,Sébastien Jan,Regine Trebossen,Frédéric Dollé,Bertrand Tavitian,Bertrand Tavitian,Filomena Mattner,Andrew Katsifis +13 more
TL;DR: The new PBR ligand CLINME is described as an alternative to PK11195 and performs better than [11C]PK11195 in this model of local acute neuroinflammation and compared with the reference compound, using autoradiography and PET imaging.
Journal ArticleDOI
Imaging brain cholinergic activity with positron emission tomography: its role in the evaluation of cholinergic treatments in Alzheimer's dementia.
TL;DR: Positron emission tomography has the potential to identify Alzheimer's disease during early disease, and it can be used to establish whether early interventions can prevent or delay further development.
Journal ArticleDOI
Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis.
TL;DR: The results demonstrate that the PET imaging technique with specific labeled compounds in combination with microdialysis and a behavioral cognition task could be a useful method to clarify the mechanism of drugs in the living brains of experimental animals.
Journal ArticleDOI
Methodological aspects for in vitro characterization of receptor binding using 11C-labeled receptor ligands: a detailed study with the benzodiazepine receptor antagonist [11C]Ro 15-1788.
Wiebke Sihver,Sven Sihver,Mats Bergström,Tetsuhito Murata,Kiyoshi Matsumura,Kiyoshi Matsumura,Hirotaka Onoe,Hirotaka Onoe,Yvonne Andersson,Peter Bjurling,Karl-Johan Fasth,Göran Westerberg,Matthias Ögren,Gunilla Jacobsson,Hans Lundqvist,Lars Oreland,Yasuyoshi Watanabe,Bengt Långström +17 more
TL;DR: Receptor-ligand kinetics, including depletion, association and dissociation, saturation and displacement were evaluated with good results through the use of short-lived radiotracers and storage phosphor plates.
Journal ArticleDOI
In vitro positron emission tomography (PET): use of positron emission tracers in functional imaging in living brain slices.
Kiyoshi Matsumura,Mats Bergström,Hirotaka Onoe,Hajime Takechi,Göran Westerberg,Gunnar Antoni,Peter Bjurling,Gunilla B. Jacobson,Bengt Långström,Yasuyoshi Watanabe +9 more
TL;DR: It is demonstrated that positron emitter-labeled tracers in combination with storage phosphor screens are useful for functional imaging of living brain slices as a novel neuroscience technique.