Reaction of chromium(VI) with glutathione or with hydrogen peroxide: identification of reactive intermediates and their role in chromium(VI)-induced DNA damage.
TLDR
The nature of chromium(VI)-induced DNA damage appears to be dependent on the reactive intermediates, i.e. chromium (V) or hydroxyl radical, produced during the reduction of chromation(VI).Abstract:
The types of reactive intermediates generated upon reduction of chromium(VI) by glutathione or hydrogen peroxide and the resulting DNA damage have been determined. In vitro, reaction of chromium(VI...read more
Citations
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Interactions of chromium with microorganisms and plants
Carlos Cervantes,Jesús Campos-García,Silvia Devars,Félix Gutiérrez-Corona,Herminia Loza-Tavera,Juan Carlos Torres-Guzmán,Rafael Moreno-Sánchez +6 more
TL;DR: The interactions of bacteria, algae, fungi and plants with Cr and its compounds are summarized and proposed as potential biotechnological tools for the bioremediation of Cr pollution.
Journal ArticleDOI
Protein kinase C signaling and oxidative stress.
Rayudu Gopalakrishna,Susan Jaken +1 more
TL;DR: KPCs contain unique structural features that are susceptible to oxidative modification, and are a logical candidate for redox modification by oxidants and antioxidants that may in part determine their cancer-promoting and anticancer activities, respectively.
Journal ArticleDOI
Mechanisms of chromium toxicity, carcinogenicity and allergenicity: Review of the literature from 1985 to 2000
A D Dayan,Alan J. Paine +1 more
TL;DR: Biochemical studies of the DNA-damaging effects and of the pathogenesis of the allergic reactions to chromium ions have not kept up with advances in understanding of the molecular basis of the effects of other carcinogens and allergens.
Journal ArticleDOI
Mechanisms of Chromium Carcinogenicity and Toxicity
TL;DR: The chemical nature of chromium compounds and how these properties impact upon the interactions ofchromium with cellular and genetic targets, including animal and human hosts, are discussed.
Toxicological Profile for Chromium
Sharon Wilbur,Henry Abadin,Mike Fay,Dianyi Yu,Brian Tencza,Lisa Ingerman,Julie M Klotzbach,Shelly James +7 more
TL;DR: This public health statement tells you about chromium and the effects of exposure to it.
References
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The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system.
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Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro.
TL;DR: An in vitro Fenton system was established that generates DNA strand breaks and inactivates bacteriophage and that also reproduces the suppression of DNA damage by high concentrations of peroxide.
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Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues
Yoshiyuki Kuchino,F Mori,Hiroshi Kasai,Hideo Inoue,Shigenori Iwai,Kazunobu Miura,Eiko Ohtsuka,Susumu Nishimura +7 more
TL;DR: The syn-thetic oligodeoxynucleotides, with or without an 8-OH-dG residue in a specified position, were chemically synthesized and used as templates for DNA synthesis under the conditions of the dideoxy chain termination sequencing method.
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Hydroxyl Free Radical Adduct of Deoxyguanosine: Sensitive Detection and Mechanisms of Formation
TL;DR: It was found that ferrous ion, but not ferric ion, was effective in forming 8-OH-dG, and the hydroxyl free radical scavenging agents, thiourea and ethanol, were very effective in quenching Fe(11) mediated 8- OH- dG formation, but superoxide dismutase had very little effect.
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In vivo formation of single-strand breaks in DNA by hydrogen peroxide is mediated by the Haber-Weiss reaction
TL;DR: The chelator therefore removes iron from the chromatin, and although the Fe-EDTA complex formed is capable of reacting with H2O2, the OH radical generated under these conditions is not close enough to hit DNA.