Reactive oxygen species and male reproductive hormones
Mahsa Darbandi,Sara Darbandi,Ashok Agarwal,Pallav Sengupta,Damayanthi Durairajanayagam,Ralf Henkel,Mohammad Reza Sadeghi +6 more
TLDR
An understanding of the disruptive effects of ROS on male reproductive hormones would encourage further investigations directed towards the prevention of ROS-mediated hormonal imbalances, which in turn could help in the management of male infertility.Abstract:
Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential There are numerous exogenous and endogenous factors that are able to induce excessive production of reactive oxygen species (ROS) beyond that of cellular antioxidant capacity, thus causing oxidative stress In turn, oxidative stress negatively affects male reproductive functions and may induce infertility either directly or indirectly by affecting the hypothalamus-pituitary-gonadal (HPG) axis and/or disrupting its crosstalk with other hormonal axes This review discusses the important exogenous and endogenous factors leading to the generation of ROS in different parts of the male reproductive tract It also highlights the negative impact of oxidative stress on the regulation and cross-talk between the reproductive hormones It further describes the mechanism of ROS-induced derangement of male reproductive hormonal profiles that could ultimately lead to male infertility An understanding of the disruptive effects of ROS on male reproductive hormones would encourage further investigations directed towards the prevention of ROS-mediated hormonal imbalances, which in turn could help in the management of male infertilityread more
Citations
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Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management
TL;DR: Physiological ROS production, roles of genetic and epigenetic factors on the OS and male infertility with various mechanisms such as lipid peroxidation, DNA damage, and disorder of male hormone profile, inflammation, and varicocele are described.
Journal ArticleDOI
Hormones and oxidative stress: an overview
TL;DR: An attempt to understand the impact of free radical generation and cross talk between the hormones modulating antioxidant defence system under various pathophysiological conditions.
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A Comparison Between Two Assays for Measuring Seminal Oxidative Stress and their Relationship with Sperm DNA Fragmentation and Semen Parameters.
Sheryl T. Homa,Anna M Vassiliou,Jesse Stone,Aideen P Killeen,Andrew Dawkins,Jingyi Xie,Farley Gould,Jonathan Ramsay +7 more
TL;DR: The results demonstrate the multi-dimensional nature of oxidative stress and that neither assay can be used alone in the diagnosis of OS, especially in cases of leukocytospermia.
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Environmental contaminants and male infertility: Effects and mechanisms.
TL;DR: The escalating prevalence of male infertility and decreasing trend in sperm quality have been correlated with rapid industrialisation and the associated discharge of an excess of synthetic substances into the environment and the possible mechanisms of action are discussed.
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The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review.
TL;DR: There is not enough evidence to prove the relationship between ER stress and male infertility in human, but most studies in this review found that ER stress was correlated with male reproduction and infertility in animal models.
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