Open AccessJournal Article
Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation
TLDR
This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard and the methods of estimate and testing of AUC and its testing in single diagnostic test and also comparative studies.Abstract:
This review provides the basic principle and rational for ROC analysis of rating and continuous diagnostic test results versus a gold standard. Derived indexes of accuracy, in particular area under the curve (AUC) has a meaningful interpretation for disease classification from healthy subjects. The methods of estimate of AUC and its testing in single diagnostic test and also comparative studies, the advantage of ROC curve to determine the optimal cut off values and the issues of bias and confounding have been discussed.read more
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Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19.
Aymeric Silvin,Nicolas Chapuis,Garett Dunsmore,Anne-Gaëlle Goubet,Agathe Dubuisson,Lisa Derosa,Carole Almire,Clémence Hénon,Olivier Kosmider,Nathalie Droin,Philippe Rameau,Cyril Catelain,Alexia Alfaro,Charles Dussiau,Chloé Friedrich,Elise Sourdeau,Nathalie Marin,T.-A. Szwebel,Delphine Cantin,Luc Mouthon,Didier Borderie,Marc Deloger,Delphine Bredel,Severine Mouraud,Damien Drubay,Muriel Andrieu,Anne-Sophie Lhonneur,Véronique Saada,Annabelle Stoclin,Christophe Willekens,Fanny Pommeret,Frank Griscelli,Lai Guan Ng,Zheng Zhang,Pierre Bost,Pierre Bost,Ido Amit,Fabrice Barlesi,Aurélien Marabelle,Frédéric Pène,Bertrand Gachot,Fabrice Andre,Fabrice Andre,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Michaela Fontenay,Eric Solary,Eric Solary +51 more
TL;DR: It is shown that calprotectin plasma level and a routine flow cytometry assay detecting decreased frequencies of non-classical monocytes could discriminate patients who develop a severe COVID-19 form, suggesting a predictive value that deserves prospective evaluation.
Journal ArticleDOI
Comparison of deep learning approaches to predict COVID-19 infection
TL;DR: Clinical predictive models trained on laboratory findings could be used to predict COVID-19 infection, and can be helpful for medical experts to prioritize the resources correctly.
Journal ArticleDOI
Angiopoietin-2 as a marker of endothelial activation is a good predictor factor for intensive care unit admission of COVID-19 patients.
David M. Smadja,Coralie L. Guerin,Coralie L. Guerin,Richard Chocron,Nader Yatim,Jeremy Boussier,Nicolas Gendron,Lina Khider,Jérôme Hadjadj,Guillaume Goudot,Benjamin Debuc,Philippe Juvin,Caroline Hauw-Berlemont,Jean Loup Augy,Nicolas Peron,Emmanuel Messas,Benjamin Planquette,Olivier Sanchez,Bruno Charbit,Pascale Gaussem,Darragh Duffy,Benjamin Terrier,Tristan Mirault,Jean Luc Diehl +23 more
TL;DR: Angiopoietin-2 is a relevant predictive factor for ICU direct admission in COVID-19 patients with criteria of hospitalization for referral to intensive care unit (ICU) and/or respiratory worsening, and this result showing an endothelial activation reinforces the hypothesis of a CO VID-19-associated microvascular dysfunction.
Journal ArticleDOI
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
Nour K. Majbour,Nour K. Majbour,Nishant N. Vaikath,Nishant N. Vaikath,Karin van Dijk,Mustafa T. Ardah,Shiji Varghese,Louise Buur Vesterager,Liliana P. Montezinho,Stephen Poole,Bared Safieh-Garabedian,Takahiko Tokuda,Charlotte E. Teunissen,Henk W. Berendse,Wilma D.J. van de Berg,Omar M. A. El-Agnaf +15 more
TL;DR: The combination of CSF o-/t- α-syn, p-S129-α-syn and p-tau provided the best fitting predictive model for discriminating PD patients from controls and correlated significantly with the severity of PD motor symptoms.
Journal ArticleDOI
Prospects for point-of-care pathogen diagnostics using surface-enhanced Raman scattering (SERS)
TL;DR: The potential impact of SERS in addressing unmet needs in pathogen diagnostics both in a traditional clinical setting and in the point of care (POC) arena is examined.
References
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Journal ArticleDOI
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
TL;DR: A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the "rating" method, or by mathematical predictions based on patient characteristics, is presented and it is shown that in such a setting the area represents the probability that a randomly chosen diseased subject is (correctly) rated or ranked with greater suspicion than a random chosen non-diseased subject.
Journal ArticleDOI
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.
TL;DR: A nonparametric approach to the analysis of areas under correlated ROC curves is presented, by using the theory on generalized U-statistics to generate an estimated covariance matrix.
Book
Signal detection theory and psychophysics
David M. Green,John A. Swets +1 more
TL;DR: This book discusses statistical decision theory and sensory processes in signal detection theory and psychophysics and describes how these processes affect decision-making.
Journal ArticleDOI
Measuring the accuracy of diagnostic systems
TL;DR: For diagnostic systems used to distinguish between two classes of events, analysis in terms of the "relative operating characteristic" of signal detection theory provides a precise and valid measure of diagnostic accuracy.
Journal ArticleDOI
A method of comparing the areas under receiver operating characteristic curves derived from the same cases.
TL;DR: This paper refines the statistical comparison of the areas under two ROC curves derived from the same set of patients by taking into account the correlation between the areas that is induced by the paired nature of the data.