Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation
TLDR
It is shown that ligand engagement of TCR-CD3 induces a conformational change that exposes a proline-rich sequence in CD3 epsilon and results in recruitment of the adaptor protein Nck, which is critical for maturation of the immune synapse and for T cell activation.About:
This article is published in Cell.The article was published on 2002-06-28 and is currently open access. It has received 448 citations till now. The article focuses on the topics: T cell receptor complex & Immunological synapse.read more
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T cell activation.
TL;DR: This year marks the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR), with a description of the current state of the understanding of TCR signaling and a summary of recent findings.
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Positive and Negative Selection of T Cells
TL;DR: The current state of the field regarding the natural ligands and molecular factors required for positive and negative selection are summarized and a model for how these disparate outcomes can be signaled via the same receptor is discussed.
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How TCRs Bind MHCs, Peptides, and Coreceptors
TL;DR: The structural basis for MHC restriction and signaling remains elusive as no structural features that define a common binding mode or signaling mechanism have yet been gleaned from the current set of TCR/pMHC complexes.
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Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells.
Adam D. Douglass,Ronald D. Vale +1 more
TL;DR: It is shown that the coreceptor CD2, the adaptor protein LAT, and tyrosine kinase Lck cocluster in discrete microdomains in the plasma membrane of signaling T cells, which require protein-protein interactions mediated through phosphorylation of LAT and are not maintained by interactions with actin or lipid rafts.
Central tolerance: learning selfcontrol in the thymus
TL;DR: In the past few years, there has been a flurry of discoveries and advancements in our understanding of how the thymus prepares T cells to exist at peace in normal healthy tissue: that is, to be self-tolerant as mentioned in this paper.
References
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Three-dimensional segregation of supramolecular activation clusters in T cells
TL;DR: The three-dimensional distribution of receptors and intracellular proteins that cluster at the contacts between T cells and APCs during antigen-specific interactions, Surprisingly, instead of showing uniform oligomerization, these proteins clustered into segregated three- dimensional domains within the cell contacts.
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Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor STUDY OF Lck- AND FynT-DEPENDENT T CELL ACTIVATION
Jeffrey Herbert Hanke,Joseph P. Gardner,Robert L. Dow,Paul S. Changelian,William H. Brissette,Weringer Elora Jeanne,Brian A. Pollok,Patricia A. Connelly +7 more
TL;DR: This compound offers a useful new tool for examining the role of the Lck and FynT tyrosine kinases versus ZAP-70 in T cell activation as well as the roles of other Src family kinases in receptor function.
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The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.
Michael L. Dustin,John A. Cooper +1 more
TL;DR: This review focuses on the recent convergence of cell biology and immunology studies to explain the role of the actin cytoskeleton in creating the molecular basis for immunological synapse formation and T cell signaling.
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Switching Signals On or Off by Receptor Dimerization
Arthur Weiss,Joseph Schlessinger +1 more
TL;DR: Receptor dimerization is essential target proteins and oligomerization has been established as a universal mechanism for the activation of hormone and growth of enzymes: transmembrane receptor-like PTPs, and cytoplasmic P TPs.