Journal ArticleDOI
Redox properties of serum albumin
TLDR
The findings suggest that a redox change in HSA is related to the oxidation of several amino acid residues by different oxidants, and the ratio of the oxidized form to the normal form of albumin (HMA/HNA) could serve as a useful marker for evaluating systemic redox states, which would be useful for the evaluation of disease progression and therapeutic efficacy.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-12-01. It has received 163 citations till now. The article focuses on the topics: Serum albumin & Oxidative stress.read more
Citations
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Journal ArticleDOI
Systemic inflammation in decompensated cirrhosis: Characterization and role in acute-on-chronic liver failure.
Joan Clària,Rudolf E. Stauber,Minneke J. Coenraad,Richard Moreau,Rajiv Jalan,Marco Pavesi,Alex Amoros,Esther Titos,José Alcaraz-Quiles,Karl Oettl,Manuel Morales-Ruiz,Paolo Angeli,Marco Domenicali,Carlo Alessandria,Alexander L. Gerbes,Julia Wendon,Frederik Nevens,Jonel Trebicka,Wim Laleman,Faouzi Saliba,Tania M. Welzel,Agustín Albillos,Thierry Gustot,Daniel Benten,François Durand,Pere Ginès,Mauro Bernardi,Vicente Arroyo +27 more
TL;DR: Patients with AD without ACLF showed very high baseline levels of inflammatory cytokines, HNA2, PRC, and PCC, and the strength of association of ACLF with SI was higher than with SCD, supporting SI as the primary driver of ACLf in cirrhosis.
Journal ArticleDOI
Human serum albumin, systemic inflammation, and cirrhosis
TL;DR: Human serum albumin (HSA) is one of the most frequent treatments in patients with decompensated cirrhosis, and its ability to bind lipopolysaccharide and other bacterial products, reactive oxygen species, nitric oxide and other nitrogen reactive species, and prostaglandins is an outstanding feature.
Journal ArticleDOI
Human serum albumin in cardiovascular diseases.
TL;DR: The purpose of this review is to provide an overview of the physiological properties of serum albumin, as well as prevalence, causes, prognostic value and potential contribution to the disease emergence and progression of hypoalbuminemia, and the resulting clinical implications.
Journal ArticleDOI
Ceruloplasmin and other copper binding components of blood plasma and their functions: an update
TL;DR: This review summarizes and updates knowledge of the nature and functions of ceruloplasmin and the other known and emerging copper-containing molecules in this fluid, to better understand how they contribute to copper homeostasis and consider their potential significance to health and disease.
Journal ArticleDOI
Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases
Kohei Nagumo,Motohiko Tanaka,Victor Tuan Giam Chuang,Hiroko Setoyama,Hiroshi Watanabe,Naoyuki Yamada,Kazuyuki Kubota,Motoko Tanaka,Kazutaka Matsushita,Akira Yoshida,Hideaki Jinnouchi,Makoto Anraku,Daisuke Kadowaki,Yu Ishima,Yutaka Sasaki,Masaki Otagiri,Toru Maruyama +16 more
TL;DR: In conclusion, ESI-TOFMS is a suitable high throughput method for the rapid and sensitive quantification of Cys-Cys34-HSA in a large number of samples for evaluating oxidative stress related chronic disease progression or in response to a treatment.
References
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Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
Journal Article
Heart-lung transplantation.
TL;DR: A broad overview of the various grounds upon which this difference is likely based and discuss recent advances in each area: 1) criteria for the selection of candidates and donors, 2) methods for ex-vivo preservation of donor organs, 3) technical execution of the operative procedure, and 4) prevention of postoperative infection as discussed by the authors.
Journal ArticleDOI
Redefining oxidative stress.
TL;DR: From a mechanistic standpoint, oxidative stress may be better defined as a disruption of redox signaling and control and adoption of such a definition could redirect research to identify key perturbations of red Oxidative stress-related disease processes and lead to new treatments for oxidative stressed disease processes.
Journal ArticleDOI
The antioxidants of human extracellular fluids.
TL;DR: The antioxidants in the aqueous phase of human plasma include ceruloplasmin, albumin (the protein itself and possibly also albumin-bound bilirubin), ascorbic acid, transferrin, haptoglobin, and hemopexin.
Journal ArticleDOI
The oxidative environment and protein damage
TL;DR: The major fate of oxidised proteins is catabolism by proteosomal and lysosomal pathways, but some materials appear to be poorly degraded and accumulate within cells, and the accumulation of such damaged material may contribute to a range of human pathologies.
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The thiol pool in human plasma: the central contribution of albumin to redox processes.
Physiological and pathological changes in the redox state of human serum albumin critically influence its binding properties.
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