Reelin Is a Ligand for Lipoprotein Receptors
Gabriella D'Arcangelo,Ramin Homayouni,Lakhu Keshvara,Dennis S. Rice,Michael Sheldon,Tom Curran +5 more
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The data suggest that Reelin directs neuronal migration by binding to VLDLR and ApoER2, preferably the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2).About:
This article is published in Neuron.The article was published on 1999-10-01 and is currently open access. It has received 800 citations till now. The article focuses on the topics: DAB1 & Low-density lipoprotein receptor-related protein 8.read more
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Apolipoprotein E: far more than a lipid transport protein.
Robert W. Mahley,Stanley C. Rall +1 more
TL;DR: Functional differences in the apoE isoforms that affect (or did affect) survival before the reproductive years probably account, at least in part, for the allele frequencies of the present day.
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Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study
Alessandro Guidotti,James Auta,John M. Davis,Valeria DiGiorgi Gerevini,Yogesh Dwivedi,Dennis R. Grayson,Francesco Impagnatiello,Ghanshyam N. Pandey,Christine Pesold,Rajiv P. Sharma,D.P. Uzunov,Erminio Costa +11 more
TL;DR: The selective down-regulation of RELN and GAD(67) in prefrontal cortex of patients with schizophrenia and bipolar disorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis; this plus the loss of the correlation between these 2 parameters that exists in nonpsychotic subjects support the hypotheses that these changes may be liability factors underlying psychosis.
Journal ArticleDOI
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
TL;DR: There is mounting evidence that APOE4 contributes to AD pathogenesis by modulating the metabolism and aggregation of amyloid-β peptide and by directly regulating brain lipid metabolism and synaptic functions through APOE receptors.
Journal ArticleDOI
Cell migration in the forebrain.
Oscar Marín,John L.R. Rubenstein +1 more
TL;DR: The cellular and molecular mechanisms underlying each of these types of migrations are reviewed and how emerging concepts in neuronal migration are reshaping the understanding of forebrain development in normal and pathological situations are discussed.
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Molecular motors and mechanisms of directional transport in neurons
Nobutaka Hirokawa,Reiko Takemura +1 more
TL;DR: The molecular mechanisms of directional axonal and dendritic transport are discussed with specific emphasis on the role of motor proteins and their mechanisms of cargo recognition.
References
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A receptor-mediated pathway for cholesterol homeostasis.
TL;DR: The approach was to apply the techniques of cell culture to unravel the postulated regulatory defect in FH, which led to the discovery of a cell surface receptor for a plasma cholesterol transport protein called low density lipoprotein (LDL) and to the elucidation of the mechanism by which this receptor mediates feedback control of cholesterol synthesis.
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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
TL;DR: Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the body.
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A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
Gabriella D'Arcangelo,Graham G. Miao,Shu-Cheng Chen,Holly D. Soares,James I. Morgan,Tom Curran +5 more
TL;DR: The reeler phenotype seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin.
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Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Marion Trommsdorff,Michael Gotthardt,Thomas Hiesberger,John M. Shelton,Walter Stockinger,Johannes Nimpf,Robert E. Hammer,James A. Richardson,Joachim Herz +8 more
TL;DR: It is suggested that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1, a cytosolic protein that activates tyrosine kinases.
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NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.
TL;DR: A review of published data revealed NPXY sequences in cytoplasmic domains of at least 10 other cell surface proteins, including tyrosine kinase-linked receptors of the epidermal growth factor and insulin receptor family, the beta-subunits of three integrin receptors, and the amyloid A4 precursor protein.