Journal ArticleDOI
Regulation of axial patterning of the retina and its topographic mapping in the brain.
Reads0
Chats0
TLDR
Recent studies indicate that ephrin-As control the temporal-nasal mapping of the retina in the optic tectum/superior colliculus by regulating the topographically-specific interstitial branching of retinal axons along the anterior-posterior tectal axis.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2003-02-01. It has received 238 citations till now. The article focuses on the topics: Superior colliculus & Retina.read more
Citations
More filters
Journal ArticleDOI
Axon retraction and degeneration in development and disease.
Liqun Luo,Dennis D.M. O'Leary +1 more
TL;DR: Examples of exuberant axonal projections and synaptic connections and potential cellular and molecular mechanisms that underlie axon retraction and degeneration are reviewed and how they might relate to each other in development and disease are considered.
Journal ArticleDOI
The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance
TL;DR: The role of cytoskeletal-associated proteins, as well as the cytoskeleton itself in axon outgrowth and guidance, is the subject of this article.
Journal ArticleDOI
Blood vessels and nerves: common signals, pathways and diseases
TL;DR: The realization that both blood vessels and nerves use common genetic pathways should not only form links between vascular biology and neuroscience, but also promises to accelerate the discovery of new mechanistic insights and therapeutic opportunities.
Journal ArticleDOI
Organization and Ca2+ Regulation of Adenylyl Cyclases in cAMP Microdomains
TL;DR: The regulation of many of the ACs by the ubiquitous second messenger Ca(2+) provides an overarching mechanism for integrating the activities of these two major signaling systems, and cAMP will exhibit distinct kinetics in discrete cellular domains.
Journal ArticleDOI
Molecular gradients and development of retinotopic maps
TL;DR: The Eph family of receptor tyrosine kinases and their ligands, the ephrins, remain the only molecules that meet all criteria for graded topographic guidance molecules, although others fulfill some criteria.
References
More filters
Journal ArticleDOI
Chemoaffinity in the Orderly Growth of Nerve Fiber Patterns and Connections
TL;DR: The hypothesis, 18-24 in brief, suggested that the patterning of synaptic connections in the nerve centers must be handled instead by the growth mechanism directly, independently of function, and with very strict selectivity governing synaptic formation from the beginning.
Journal ArticleDOI
In vitro guidance of retinal ganglion cell axons by rags, a 25 kda tectal protein related to ligands for eph receptor tyrosine kinases
Uwe Drescher,Claus Kremoser,Claudia Handwerker,Jürgen Löschinger,Masaharu Noda,Friedrich Bonhoeffer +5 more
TL;DR: A GPI-anchored, 25 kDa glycoprotein that is a good candidate for a molecule involved in the guidance of temporal retinal axons during the formation of the topographically ordered retinotectal projection is purified and cloned and named RAGS (for repulsive axon guidance signal).
Journal ArticleDOI
Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map
TL;DR: RNA hybridization shows matching expression gradients for ELF-1 in the tectum and its receptor Mek4 in the retina and provides direct evidence for molecular complementarity of gradients in reciprocal fields, indicating roles in retinotectal development and properties predicted of topographic mapping labels.
Journal ArticleDOI
Early eye development in vertebrates.
Robert L. Chow,Richard A. Lang +1 more
TL;DR: This review provides a synthesis that combines data from classical experimentation and recent advances in understanding of early eye development, with emphasis on the events that underlie and direct neural retina formation and lens induction.
Journal ArticleDOI
Multiple roles of eph receptors and ephrins in neural development
TL;DR: The control of cell movement during development is essential for forming and stabilizing the spatial organization of tissues and cell types and Eph receptor tyrosine kinases and their ephrin ligands are key players in controlling these cell movements in many tissues and at multiple stages of patterning.