Regulation of Dendritic Spine Morphology by SPAR, a PSD-95-Associated RapGAP
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TLDR
It is reported that SPAR, a Rap-specific GTPase-activating protein (RapGAP), interacts with the guanylate kinase-like domain of PSD-95 and forms a complex with PSD -95 and NMDA receptors in brain.About:
This article is published in Neuron.The article was published on 2001-08-02 and is currently open access. It has received 387 citations till now. The article focuses on the topics: Dendritic spine morphogenesis & Dendritic spine.read more
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An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation
Melanie Rothe,Noreen Kanwal,Petra Dietmann,Franziska A. Seigfried,Annemarie Hempel,Desiree Schütz,Dominik Reim,Rebecca Engels,Alexander Linnemann,Michael J. Schmeisser,Juergen Bockmann,Michael Kühl,Tobias M. Boeckers,Susanne J. Kühl +13 more
TL;DR: The analysis of Xenopus loss-of-function mutants reveals that Sipa1l3 – a gene associated with congenital cataracts in humans – interacts with Epha4 signaling to regulate retinal and lens development.
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Involvement of the Snk-SPAR pathway in glutamate-induced excitotoxicity in cultured hippocampal neurons.
TL;DR: It is reported here that in cultured hippocampal neurons, glutamate stimulation induces the activation of Snk-SPAR pathway, and leads to a loss of mature dendritic spines, and the activation can be blocked by an NMDA receptor antagonist, MK801.
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Synaptic potentiation facilitates memory-like attractor dynamics in cultured in vitro hippocampal networks.
TL;DR: This study demonstrates that using a pharmacological treatment that has been shown to increase synaptic strength within in vitro networks of hippocampal neurons follows the dynamical postulates theorized by attractor models, and constructs a computational model to demonstrate that these synaptic perturbations can account for the Dynamical changes seen within the network.
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Ras family small GTPase-mediated neuroprotective signaling in stroke.
TL;DR: The contribution of Ras family GTPases to neuroprotective signaling cascades, including mitogen-activated protein kinase (MAPK) familyprotein kinase- and AKT/PKB-dependent signaling pathways as well as the regulation of cAMP response element binding (CREB), Forkhead box O (FoxO) and hypoxiainducible factor 1(HIF1) transcription factors, in stroke are highlighted.
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Common pathways for growth and for plasticity
Shira Knafo,José A. Esteban +1 more
TL;DR: The latest findings on two prototypical examples of shared mechanisms: the Ras-PI3K pathway and the intracellular signaling elicited by neural cell adhesion molecules interacting with growth factor receptors are reviewed.
References
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Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
TL;DR: The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95, which may affect the plasticity of excitatory synapses.
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Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
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Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
TL;DR: Direct evidence is presented that NMDA receptors exist in rat neocortex as heteromeric complexes of considerable heterogeneity, some containing both NR2A and NR2B subunits.
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Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
TL;DR: High-frequency focal synaptic stimulation induced a period of enhanced growth of small filopodia-like protrusions in dendritic regions close to the stimulating electrode and was prevented by blockade of N-methyl-D-aspartate receptors.
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Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
TL;DR: Proteomic characterization with mass spectrometry and immunoblotting of NMDAR multiprotein complexes (NRC) isolated from mouse brain indicates the NRC also participates in human cognition.