Regulation of Dendritic Spine Morphology by SPAR, a PSD-95-Associated RapGAP
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TLDR
It is reported that SPAR, a Rap-specific GTPase-activating protein (RapGAP), interacts with the guanylate kinase-like domain of PSD-95 and forms a complex with PSD -95 and NMDA receptors in brain.About:
This article is published in Neuron.The article was published on 2001-08-02 and is currently open access. It has received 387 citations till now. The article focuses on the topics: Dendritic spine morphogenesis & Dendritic spine.read more
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Dissertation
Abnormal protein phosphorylation in human amyotrophic lateral sclerosis
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Computing the Brain and the Computing Brain
TL;DR: The long-tersm end result of the collective effort by researchers in computational neuroanatomy and neuroscience at large will be a comprehensive structural and functional model of the brain.
Journal ArticleDOI
Structural differences between the SH3-HOOK-GuK domains of SAP90/PSD-95 and SAP97.
Rama Ramesh Vandanapu,Aditya K. Singh,Marina Mikhaylova,Pasham Parameshwar Reddy,Michael R. Kreutz,Yogendra Sharma +5 more
TL;DR: Equilibrium unfolding of SAP97 is highly cooperative from a native state to an unfolded state, in contrast, SAP90/PSD-95 follows a non-cooperative transition from native to unfolded states, and GdmCl-induced equilibrium unfolding of both proteins follows the two-state transitions and thus does not involve the accumulation of stable intermediate state(s).
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Long-Term Dynamical Constraints on Pharmacologically Evoked Potentiation Imply Activity Conservation within In Vitro Hippocampal Networks
TL;DR: It is shown that the effects of potentiation are persistent over time but are modulated under a conservation of spike principle, and suggested that this conservation principle might be mediated by the appearance of a resonant inter-spike interval that prevents the network from advancing towards a state of hyperexcitability.
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Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97).
Shinji Mori,Yuta Tezuka,Akihiko Arakawa,Noriko Handa,Mikako Shirouzu,Tetsu Akiyama,Shigeyuki Yokoyama +6 more
TL;DR: The crystal structure of the GK domain of human DLG1, a member of the membrane associated guanylate kinase (MAGUK) family of proteins, is solved and the side chain interactions of the C-terminal tail with theDLG1 GKdomain are similar to those of the phosphorylated LGN peptide.
References
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Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95
TL;DR: The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95, which may affect the plasticity of excitatory synapses.
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Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Florian Engert,Tobias Bonhoeffer +1 more
TL;DR: After induction of long-lasting (but not short-lasting) functional enhancement of synapses in area CA1, new spines appear on the postsynaptic dendrite, whereas in control regions on the same dendrites or in slices where long-term potentiation was blocked, no significant spine growth occurred.
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Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
TL;DR: Direct evidence is presented that NMDA receptors exist in rat neocortex as heteromeric complexes of considerable heterogeneity, some containing both NR2A and NR2B subunits.
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Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity
TL;DR: High-frequency focal synaptic stimulation induced a period of enhanced growth of small filopodia-like protrusions in dendritic regions close to the stimulating electrode and was prevented by blockade of N-methyl-D-aspartate receptors.
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Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
TL;DR: Proteomic characterization with mass spectrometry and immunoblotting of NMDAR multiprotein complexes (NRC) isolated from mouse brain indicates the NRC also participates in human cognition.