Journal ArticleDOI
Regulation of MAP kinase signaling modules by scaffold proteins in mammals.
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TLDR
The evidence that supports a physiologically relevant role of MAPK scaffold proteins in mammals is critically evaluated.Abstract:
▪ Abstract The mitogen-activated protein kinase (MAPK) group of serine/threonine protein kinases mediates the response of cells to many extracellular stimuli such as cytokines and growth factors. These protein kinases include the extracellular signal-regulated protein kinases (ERK) and two stress-activated protein kinases (SAPK), the c-Jun N-terminal kinases (JNK), and the p38 MAPK. The enzymes are evolutionarily conserved and are activated by a common mechanism that involves a protein kinase cascade. Scaffold proteins have been proposed to interact with MAPK pathway components to create a functional signaling module and to control the specificity of signal transduction. Here we critically evaluate the evidence that supports a physiologically relevant role of MAPK scaffold proteins in mammals.read more
Citations
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Rho GTPases: Biochemistry and Biology
Aron B. Jaffe,Alan Hall +1 more
TL;DR: This review presents the best characterized of these biochemical pathways that control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division.
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MAP kinase signalling pathways in cancer.
TL;DR: Recent findings and hypotheses on the role of MAPK pathways in cancer are discussed, with a focus on stress-activated pathways, which largely seem to counteract malignant transformation.
Journal ArticleDOI
Signal integration by JNK and p38 MAPK pathways in cancer development
Erwin F. Wagner,Angel R. Nebreda +1 more
TL;DR: This Review highlights the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers.
Journal ArticleDOI
Pathological roles of MAPK signaling pathways in human diseases
Eunkyung Kim,Eui Ju Choi +1 more
TL;DR: Recent findings on the roles of MAPK signaling pathways in human disorders, focusing on cancer and neurodegenerative diseases including AD, PD, and ALS are summarized.
Journal ArticleDOI
The JNK signal transduction pathway.
Claire R. Weston,Roger J. Davis +1 more
TL;DR: Insight into the role of scaffold proteins that may assemble functional JNK modules has been achieved and a small molecule pharmacological inhibitor of JNK has been described and it is likely that this drug will facilitate future studies of J NK function.
References
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Journal ArticleDOI
Signal transduction by the JNK group of MAP kinases.
TL;DR: This review will focus on the JNK group of MAP kinases, which are characterized by the sequence TEY and the two stress-activatedMAP kinases: p38 with the sequence TGY, and the c-Jun NH2-terminal kinases (JNK) with the sequences TPY.
Journal ArticleDOI
Mitogen-activated protein kinases: specific messages from ubiquitous messengers
TL;DR: Recent findings are described that provide insight into ways that the regulation, structure, and localization of MAPKs and the participation of adapters and scaffolds can help determine biological outcomes.
Journal ArticleDOI
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
Louis M. Luttrell,Stephen S. G. Ferguson,Yehia Daaka,William E. Miller,Stuart Maudsley,G. J. Della Rocca,Fang-Tsyr Lin,H. Kawakatsu,K. Owada,D. K. Luttrell,Marc G. Caron,Robert J. Lefkowitz +11 more
TL;DR: Data suggest that beta-arrestin binding, which terminates receptor-G protein coupling, also initiates a second wave of signal transduction in which the "desensitized" receptor functions as a critical structural component of a mitogenic signaling complex.
Journal ArticleDOI
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
TL;DR: In this article, the Src family tyrosine kinases and components of the ERK1/2 and JNK3 MAP kinase cascades are recruited to GPCR-occupied GPCRs by recruiting these kinases to the receptor.
Journal ArticleDOI
Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK
Audrey Minden,Anning Lin,Martin McMahon,Carol A. Lange-Carter,Benoit Dérijard,Roger J. Davis,Gary L. Johnson,Michael Karin +7 more
TL;DR: These results demonstrate the existence of two distinct Ras-dependent MAPK cascades--one initiated by Raf-1 leading to ERK activation, and the other initiated by MEKK leading to JNK activation.