Regulation of the balance of one-carbon metabolism in Saccharomyces cerevisiae.
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TLDR
A model for how cells balance the need to supplement their one-carbon pools when charged folates are limiting or when glycine is in excess is proposed and it is proposed that under normal conditions, cytoplasmic 5,10-CH2-H4folate is mainly directed to generating methyl groups via methionine, whereas one- carbon units generated from glycine in mitochondria are more directed to purine biosynthesis.About:
This article is published in Journal of Biological Chemistry.The article was published on 2000-10-06 and is currently open access. It has received 90 citations till now. The article focuses on the topics: Glycine cleavage system & Serine.read more
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Comparative assessment of large-scale data sets of protein-protein interactions.
Christian von Mering,Roland Krause,Berend Snel,Michael Cornell,Stephen G. Oliver,Stanley Fields,Peer Bork +6 more
TL;DR: Comprehensive protein–protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function and are compared with each other and with a reference set of previously reported protein interactions.
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Understanding the antimicrobial mechanism of TiO 2 -based nanocomposite films in a pathogenic bacterium
Anna Kubacka,María Suárez Diez,David Rojo,Rafael Bargiela,Sergio Ciordia,Inés Zapico,Juan Pablo Albar,Coral Barbas,Vitor A. P. Martins dos Santos,Marcos Fernández-García,Manuel Ferrer +10 more
TL;DR: The present work provides the first solid foundation for the biocidal action of titania and may have an impact on the design of highly active photobiocidal nanomaterials.
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APSES Proteins Regulate Morphogenesis and Metabolism in Candida albicans
Thomas Doedt,Shankarling Krishnamurthy,Dirk P. Bockmühl,Bernd Tebarth,Christian Stempel,Claire L. Russell,Alistair J. P. Brown,Joachim F. Ernst +7 more
TL;DR: The results suggest that Efh1p supports the regulatory functions of the primary regulator, Efg1p, and indicate a dual role for these APSES proteins in the regulation of fungal morphogenesis and metabolism.
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When transcriptome meets metabolome: fast cellular responses of yeast to sudden relief of glucose limitation
Made Tri Ari Penia Kresnowati,W.A. van Winden,Marinka J. H. Almering,A ten Pierick,Cor Ras,Theo A. Knijnenburg,Pascale Daran-Lapujade,Jack T. Pronk,J. J. Heijnen,J.M. Daran +9 more
TL;DR: The short‐term dynamics of the transcriptome revealed a remarkably fast decrease in the average half‐life of downregulated genes, which can be interpreted both as an additional nucleotide salvage pathway and an additional level of glucose‐induced regulation of gene expression.
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Lipoic Acid Metabolism in Microbial Pathogens
TL;DR: The role of lipoate metabolism in bacterial, fungal, and protozoan pathogens and how these organisms have employed this metabolism to adapt to niche environments are surveyed.
References
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Improved method for high efficiency transformation of intact yeast cells.
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Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site
Leonard Guarente,Thomas L. Mason +1 more
TL;DR: expression of the iso-1-cytochrome c gene of Saccharomyces cerevisiae, CYC1, is tightly regulated by levels of intracellular heme, suggesting that in the wildtype, heme controls initiation per se and not translation or mRNA stability.
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Global response of Saccharomyces cerevisiae to an alkylating agent
TL;DR: DNA chip technology enables simultaneous examination of how approximately 6,200 Saccharomyces cerevisiae gene transcript levels, representing the entire genome, respond to environmental change, and it is shown that, after exposure to the alkylating agent methyl methanesulfonate, approximately 325 gene transcripts levels are increased and approximately 76 are decreased.
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Compartmentation of folate-mediated one-carbon metabolism in eukaryotes.
TL;DR: This review is a summary of recent results that suggest that folate‐mediated one‐carbon metabolism is highly compartmentalized in eukaryotic cells.
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5-Formyltetrahydrofolate polyglutamates are slow tight binding inhibitors of serine hydroxymethyltransferase.
Patrick J. Stover,Verne Schirch +1 more
TL;DR: The results are discussed in terms of the possible role of 5-formyltetrahydrofolate polyglutamates in regulation of one-carbon metabolism.