Repetitive transcranial magnetic stimulation-induced changes in sensorimotor coupling parallel improvements of somatosensation in humans
Burkhard Pleger,Felix Blankenburg,Sven Bestmann,Christian C. Ruff,Katja Wiech,Klaas E. Stephan,Karl J. Friston,Raymond J. Dolan +7 more
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TLDR
It is shown that 5 Hz rTMS over primary somatosensory cortex (SI) induces a reconfiguration of activity patterns in a sensorimotor network, comprising the stimulated region and ipsilateral primary motor cortex (MI).Abstract:
Repetitive transcranial magnetic stimulation (rTMS) is an established technique for non-invasive stimulation of human cortex. Although studies have shown an influence of rTMS on single cortical regions and on simple behavioral response patterns, its influences on the dynamics of task-related activity in cortical networks have not been characterized. We provide such a characterization by showing that 5 Hz rTMS over primary somatosensory cortex (SI) induces a reconfiguration of activity patterns in a sensorimotor network, comprising the stimulated region and ipsilateral primary motor cortex (MI). These plastic changes endure for up to 120 min and are correlated with behavioral improvement in discrimination. Dynamic causal modeling showed that this reconfiguration could be explained by an rTMS-induced increase in SI excitability (self-connection) and an increase in the effective connectivity from SI to MI. Thus, our data demonstrate that rTMS can temporarily induce behaviorally relevant reorganization within a complex cortical network underlying human somatosensory experience.read more
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Measuring and manipulating brain connectivity with resting state functional connectivity magnetic resonance imaging (fcMRI) and transcranial magnetic stimulation (TMS)
TL;DR: The combination of TMS and resting state fcMRI has the potential to accelerate the translation of both techniques into the clinical realm and promises a new approach to the diagnosis and treatment of neurological and psychiatric diseases that demonstrate network pathology.
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Consensus paper: Combining transcranial stimulation with neuroimaging
Hartwig R. Siebner,Hartwig R. Siebner,Til Ole Bergmann,Sven Bestmann,Sven Bestmann,Marcello Massimini,Heidi Johansen-Berg,Hitoshi Mochizuki,Daryl E. Bohning,Erie D. Boorman,Sergiu Groppa,Carlo Miniussi,Alvaro Pascual-Leone,Reto Huber,Paul C.J. Taylor,Risto J. Ilmoniemi,Risto J. Ilmoniemi,Luigi De Gennaro,Antonio P. Strafella,Seppo Kähkönen,Stefan Klöppel,Giovanni B. Frisoni,Mark S. George,Mark Hallett,Stephan A. Brandt,Matthew F. S. Rushworth,Ulf Ziemann,John C. Rothwell,Nick S. Ward,Nick S. Ward,Leonardo G. Cohen,Jürgen Baudewig,Tomáš Paus,Tomáš Paus,Yoshikazu Ugawa,Paolo Maria Rossini +35 more
TL;DR: How TMS can be combined with various neuroimaging techniques to investigate human brain function is reviewed and the use of specific brain mapping techniques in conjunction with TMS is discussed.
Journal ArticleDOI
Modulating cortical connectivity in stroke patients by rTMS assessed with fMRI and dynamic causal modeling
Christian Grefkes,Dennis A. Nowak,Ling E. Wang,Manuel Dafotakis,Simon B. Eickhoff,Gereon R. Fink +5 more
TL;DR: Connectivity analyses suggest that both a reduction of pathological transcallosal influences (originating from contralesional M1) and a restitution of ipsilesional effective connectivity between SMA and M1 underlie improved motor performance.
Journal ArticleDOI
Functionally Specific Reorganization in Human Premotor Cortex
Jacinta O'Shea,Heidi Johansen-Berg,Danielle Trief,Silke M. Göbel,Matthew F. S. Rushworth,Matthew F. S. Rushworth +5 more
TL;DR: FMRI investigated short-term reorganization in right PMd after transcranial magnetic stimulation disrupted the dominant left PMd, which is specialized for action selection, finding a pattern of functional reorganization specific to task periods of action selection as opposed to action execution.
Journal ArticleDOI
Efficacy of repetitive transcranial magnetic stimulation/transcranial direct current stimulation in cognitive neurorehabilitation.
Carlo Miniussi,Stefano F. Cappa,Leonardo G. Cohen,Agnes Flöel,Felipe Fregni,Michael A. Nitsche,Massimiliano Oliveri,Alvaro Pascual-Leone,Walter Paulus,Alberto Priori,Vincent Walsh +10 more
TL;DR: Preliminary evidence suggests that cortical stimulation may play a role in treating aphasia, unilateral neglect, and other cognitive disorders and brain stimulation is indeed an exciting opportunity in the field of cognitive neurorehabilitation, which is clearly in need of further research.
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