Journal ArticleDOI
Replicative senescence promotes prothrombotic responses in endothelial cells: Role of NADPH oxidase- and cyclooxygenase-derived oxidative stress
Grazielle C. Silva,Malak Abbas,Sonia Khemais-Benkhiat,Mélanie Burban,Thaís P. Ribeiro,Florence Toti,Noureddine Idris-Khodja,Steyner F. Cortes,Valérie B. Schini-Kerth +8 more
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TLDR
Replicative endothelial senescence promotes a prothrombotic response involving the down‐ regulation of the protective NO pathway and the upregulation of the NADPH oxidase‐ and COXs‐dependent oxidative stress pathway promoting TF expression and activity.About:
This article is published in Experimental Gerontology.The article was published on 2017-07-01. It has received 32 citations till now. The article focuses on the topics: NADPH oxidase & Endothelium.read more
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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
TL;DR: Coppe et al. as mentioned in this paper showed that human cells induced to senesce by genotoxic stress secrete myriad factors associated with inflammation and malignancy, including interleukin (IL)-6 and IL-8.
Journal ArticleDOI
Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation.
Gabor A. Fulop,Gabor A. Fulop,Tamas Kiss,Tamas Kiss,Stefano Tarantini,Priya Balasubramanian,Andriy Yabluchanskiy,Eszter Farkas,Ferenc Bari,Zoltan Ungvari,Anna Csiszar,Anna Csiszar +11 more
TL;DR: Evidence is provided that aging and Nrf2 dysfunction promote cellular senescence in cerebral vessels, which may potentially cause or exacerbate age-related pathology.
Journal ArticleDOI
Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
TL;DR: Senescent cells belonging to various cell types are a dominant and chronic source of a large array of pro-inflammatory cytokines and various additional plaque destabilizing factors, being involved with various aspects of atherosclerosis pathogenesis.
Journal ArticleDOI
Potential mechanisms underlying cardiovascular protection by polyphenols: Role of the endothelium.
Min-Ho Oak,Cyril Auger,E. Belcastro,Sin-Hee Park,Hyun-Ho Lee,Valérie B. Schini-Kerth,Valérie B. Schini-Kerth +6 more
TL;DR: Both experimental and clinical evidences indicating that polyphenols are able to promote endothelial and vascular health, as well as the underlying mechanisms are discussed.
Journal ArticleDOI
Shared Features of Endothelial Dysfunction between Sepsis and Its Preceding Risk Factors (Aging and Chronic Disease)
Jesus F. Bermejo-Martin,Marta Martin-Fernandez,Cristina López-Mestanza,Patricia Duque,Raquel Almansa +4 more
TL;DR: In this article, the authors reviewed the features of endothelial dysfunction shared by sepsis, aging and the chronic conditions preceding this disease, and concluded that chronic diseases impair the mechanisms of the endothelial reparation.
References
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Journal ArticleDOI
The limited in vitro lifetime of human diploid cell strains
TL;DR: The survival curves obtained with human diploid cell strains are comparable to “multiple-hit” or “ multiple-target” curves obtain with other biological systems where an initial threshold dose is required before an exponential form of the curve is established.
Journal ArticleDOI
Prevention of Venous Thromboembolism* American College of Chest Physicians Evidence- Based Clinical Practice Guidelines (8th Edition)
William H. Geerts,David Bergqvist,Graham F. Pineo,John A. Heit,Charles M. Samama,Michael R. Lassen,Clifford W. Colwell +6 more
TL;DR: This article discusses the prevention of venous thromboembolism (VTE) and is part of the Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
Journal ArticleDOI
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe,Christopher K. Patil,Francis Rodier,Francis Rodier,Yun-Yu Sun,Denise P. Muñoz,Denise P. Muñoz,Joshua Goldstein,Peter S. Nelson,Pierre-Yves Desprez,Pierre-Yves Desprez,Judith Campisi,Judith Campisi +12 more
TL;DR: A cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment is suggested.
Journal Article
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
TL;DR: Coppe et al. as mentioned in this paper showed that human cells induced to senesce by genotoxic stress secrete myriad factors associated with inflammation and malignancy, including interleukin (IL)-6 and IL-8.
Journal ArticleDOI
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises Part I: Aging Arteries: A “Set Up” for Vascular Disease
Edward G. Lakatta,Daniel Levy +1 more
TL;DR: Burt et al. as mentioned in this paper showed that a substantial percentage of older, community-dwelling, otherwise healthy volunteers have evidence of inducible ischemia during combined thallium/ECG treadmill stress testing, and their prognosis is poor compared with their counterparts without subclinical coronary disease.
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Malak Abbas,Laurence Jesel,Cyril Auger,Lamia Amoura,Nathan Messas,Guillaume Manin,Cordula Rumig,Antonio J. León-González,Thaís P. Ribeiro,Grazielle C. Silva,Raghida Abou-Merhi,Eva Hamade,Markus Hecker,Yannick Georg,Nabil Chakfe,Patrick Ohlmann,Valérie B. Schini-Kerth,Florence Toti,Olivier Morel +18 more