Responses of the Peyer's Patches in Germ-Free Mice to Antigenic Stimulation.
Morris Pollard,Nehama Sharon +1 more
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There was no demonstrable immunological response by the germ-free mouse to Streptococcus faecalis and the Peyer's patches were activated if antigen was absorbed from the intestinal lumen into the circulation but not if the antigen was administered parenterally.Abstract:
Lymph nodes, spleens, and Peyer's patches of germ-free mice are relatively inactive. The tissues are small and contain rare, small, indistinct, germinal zones. When exposed to antigenic stimuli (Salmonella paratyphi A and lymphocytic choriomeningitis virus), the tissues become larger and germinal zones appear coincident with antibodies in the blood. The Peyer's patches were activated if antigen was absorbed from the intestinal lumen into the circulation but not if the antigen was administered parenterally. There was no demonstrable immunological response by the germ-free mouse to Streptococcus faecalis.read more
Citations
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References
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Cellular Basis of the Immunological Defects in Thymectomized Mice
TL;DR: The following three articles describe experiments aimed at defining the nature of the cellular basis for the immunological deficiency of neonatally thymectomized mice.
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A mammalian equivalent of the avian bursa of fabricius
MaxD. Cooper,DanielY.E. Perey,MartinF. Mckneally,AnnE. Gabrielsen,D. E. R. Sutherland,Robert A. Good +5 more
Journal ArticleDOI
Determination of germfree status
TL;DR: A general scheme for determining the germfree status of an animal is presented that generally meet the nutritional, oxygen, and temperature requirements for growth of most bacterial and mycologic forms that have the greatest probability of gaining entry to the germ free apparatus through a fault in the mechan*.
Journal ArticleDOI
Radiation-induced leukemia in germfree mice.
Morris Pollard,Taiju Matsuzawa +1 more
TL;DR: Lymphatic leukemia was elicited by whole-body X-irradiation in germfree mice of Swiss-Webster, C3H, and C57 Bl strains and the occult leukemogenic agent was perpetuated in successive generations of mice by “vertical” passage, through the ovum or through the placenta.