Journal ArticleDOI
Resveratrol and Alzheimer's Disease: Mechanistic Insights.
Touqeer Ahmed,Sehrish Javed,Sana Javed,Ameema Tariq,Dunja Šamec,Silvia Tejada,Seyed Fazel Nabavi,Nady Braidy,Seyed Mohammad Nabavi +8 more
TLDR
The current review discusses the multiple potential mechanisms of action of resveratrol on the pathobiology of AD and multiple strategies aimed at increasing the bioavailability of res veratrol have been addressed.Abstract:
Alzheimer's disease (AD) is the leading cause of dementia in the elderly and is characterized by progressive cognitive and memory deficits. The pathological hallmarks of AD include extracellular senile plaques and intracellular neurofibrillary tangles. Although several mechanisms have been used to explain the underlying pathogenesis of AD, current treatment regimens remain inadequate. The neuroprotective effects of the polyphenolic stilbene resveratrol (3,5,4'-trihydroxy-trans-stilbene) have been investigated in several in vitro and in vivo models of AD. The current review discusses the multiple potential mechanisms of action of resveratrol on the pathobiology of AD. Moreover, due to the limited pharmacokinetic parameters of resveratrol, multiple strategies aimed at increasing the bioavailability of resveratrol have also been addressed.read more
Citations
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Journal ArticleDOI
Resveratrol for Alzheimer's disease
TL;DR: Resveratrol is a potent activator of SIRT1, and thus may mimic caloric restriction to prevent diseases of aging in animals and in individuals with mild‐to‐moderate AD.
Journal ArticleDOI
Repairing Mitochondrial Dysfunction in Disease
TL;DR: The discovery and development of the first true mitochondrial drugs, which are now entering the clinic and are discussed in this review, are discussed.
Journal ArticleDOI
Oxidant/Antioxidant Imbalance in Alzheimer’s Disease: Therapeutic and Diagnostic Prospects
TL;DR: Current knowledge about the oxidative stress-induced impairments and compromised oxidative stress defense mechanisms in AD brain and the cross-talk between various pathophysiological insults are presented, with the focus on excessive reactive oxygen species (ROS) generation and Aβ overproduction at the early stages of the disease.
Journal ArticleDOI
Resveratrol and Brain Mitochondria: a Review
Fernanda Rafaela Jardim,Fernando Tonon de Rossi,Marielle Xavier Nascimento,Renata Gabriele da Silva Barros,Paula Agrizzi Borges,Isabella Cristina Prescilio,Marcos Roberto de Oliveira +6 more
TL;DR: The effects of resveratrol on brain mitochondria are discussed, which are of pharmacological interest in the case of neurodegenerative diseases, which involve mitochondrial impairment and increased generation of reactive species, leading to neuroinflammation and cell death.
Journal ArticleDOI
Natural Compounds for Alzheimer's Disease Therapy: A Systematic Review of Preclinical and Clinical Studies.
TL;DR: This work aims to review the natural compounds that until this date were described as having significant benefits for this neurological disease, focusing on studies that present clinical trials.
References
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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
Dohoon Kim,Dohoon Kim,Minh Dang Nguyen,Matthew M. Dobbin,Andre Fischer,Farahnaz Sananbenesi,Joseph T. Rodgers,Joseph T. Rodgers,Ivana Delalle,Joseph A. Baur,Guangchao Sui,Sean M. Armour,Pere Puigserver,Pere Puigserver,David A. Sinclair,Li-Huei Tsai +15 more
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Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid-β Peptides
TL;DR: A proteasome-dependent anti-amyloidogenic activity of resveratrol is demonstrated and it is suggested that this natural compound has a therapeutic potential in Alzheimer's disease.
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Bioavailability of resveratrol.
TL;DR: Deconjugation enzymes such as β‐glucuronidase and sulfatase, as well as specific tissue accumulation of resveratrol, may enhance resver atrol efficacy at target sites, and methylated derivatives with improved bioavailability may be important in future research.
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Metabolism and roles of stilbenes in plants
TL;DR: Stilbenes are a small family of plant secondary metabolites derived from the phenylpropanoid pathway, and produced in a number of unrelated plant species as mentioned in this paper, which have numerous implications in plant disease resistance and human health.
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Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
TL;DR: These naturally occurring stilbenes, known to be strong antioxidants and to have cancer chemopreventive activities, will add to the purported health benefits derived from the consumption of these small fruits.