Journal ArticleDOI
Review: development of clinically relevant scaffolds for vascularised bone tissue engineering.
TLDR
This review highlights the key challenges hampering widespread clinical translation of scaffold-based vascularised BTE, with a focus on the repair of large non-union defects.About:
This article is published in Biotechnology Advances.The article was published on 2013-09-01. It has received 380 citations till now.read more
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Journal ArticleDOI
Scaffolds for Bone Tissue Engineering: State of the art and new perspectives.
Livia Roseti,V. Parisi,Mauro Petretta,Carola Cavallo,Giovanna Desando,Isabella Bartolotti,Brunella Grigolo +6 more
TL;DR: It is highlighted that, despite its encouraging results, the clinical approach of Bone Tissue Engineering has not taken place on a large scale yet, due to the need of more in depth studies, its high manufacturing costs and the difficulty to obtain regulatory approval.
Journal ArticleDOI
Scaffold Design for Bone Regeneration
TL;DR: This focus of this review is on the evolution of these scaffolds as bone graft substitutes in the process of recreating the bone tissue microenvironment, including biochemical and biophysical cues.
Journal ArticleDOI
Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review
Atul A. Chaudhari,Komal Vig,Dieudonné R. Baganizi,Rajnish Sahu,Saurabh Dixit,Vida A. Dennis,Shree R. Singh,Shreekumar R. Pillai +7 more
TL;DR: Various types of scaffolding approaches and biomaterials used in the field of skin tissue engineering are discussed and more importantly their future prospects in skin tissue regeneration efforts are discussed.
Journal ArticleDOI
Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices
Tinke Marie de Witte,Tinke Marie de Witte,Lidy E. Fratila-Apachitei,Amir A. Zadpoor,Nicholas A. Peppas +4 more
TL;DR: An analysis of scaffold-based growth factor delivery strategies found in the recent literature shows great promise, both by providing sustained release over a therapeutically relevant timeframe and the potential to sequentially deliver multiple growth factors.
Journal ArticleDOI
Bioactive polymeric scaffolds for tissue engineering.
Scott Stratton,Namdev B. Shelke,Kazunori Hoshino,Swetha Rudraiah,Sangamesh G. Kumbar,Sangamesh G. Kumbar +5 more
TL;DR: 3D scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores, bioactivity and degradation rate to enable tissue regeneration are highlighted.
References
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Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
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Materials Science and Engineering: An Introduction
TL;DR: In this paper, the International System of Units (SI) is used to measure the properties of materials and their properties in the context of materials science and engineering, including properties of metal alloys.
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Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
TL;DR: It is understood that biofilms are universal, occurring in aquatic and industrial water systems as well as a large number of environments and medical devices relevant for public health, and that treatments may be based on inhibition of genes involved in cell attachment and biofilm formation.
Journal ArticleDOI
Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.