Review on plant antimicrobials: a mechanistic viewpoint
TLDR
The main antibiotic resistance mechanisms of bacteria are summarized and how phytochemicals belonging to different chemical classes could reverse the antibiotic resistance are discussed.Abstract:
Microbial resistance to classical antibiotics and its rapid progression have raised serious concern in the treatment of infectious diseases. Recently, many studies have been directed towards finding promising solutions to overcome these problems. Phytochemicals have exerted potential antibacterial activities against sensitive and resistant pathogens via different mechanisms of action. In this review, we have summarized the main antibiotic resistance mechanisms of bacteria and also discussed how phytochemicals belonging to different chemical classes could reverse the antibiotic resistance. Next to containing direct antimicrobial activities, some of them have exerted in vitro synergistic effects when being combined with conventional antibiotics. Considering these facts, it could be stated that phytochemicals represent a valuable source of bioactive compounds with potent antimicrobial activities.read more
Citations
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Antibacterial Activity of Some Flavonoids and Organic Acids Widely Distributed in Plants.
TL;DR: These compounds were generally more active against Gram-negative bacteria: Escherichia coli and Pseudomonas aeruginosa than Gram-positive ones: Enterococcus faecalis and Staphylococcus aureus and the presence of hydroxyl groups in the phenyl rings A and B did not influence on the level of their activity.
Journal ArticleDOI
Development of Electrospun Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Monolayers Containing Eugenol and Their Application in Multilayer Antimicrobial Food Packaging.
TL;DR: The here-developed multilayer fully based on polyhydroxyalkanoates (PHAs) shows a great deal of potential for antimicrobial packaging applications using biodegradable materials to increase both quality and safety of food products.
Journal ArticleDOI
Plant Secondary Metabolites in the Battle of Drugs and Drug-Resistant Bacteria: New Heroes or Worse Clones of Antibiotics?
Cyrill L. Gorlenko,Herman Yu. Kiselev,Elena V. Budanova,Andrey A. Zamyatnin,Andrey A. Zamyatnin,Larisa N. Ikryannikova +5 more
TL;DR: This short review asks the question: do antibacterial agents derived from plants have a chance to become a panacea against infectious diseases in the “post-antibiotics era”?
Journal ArticleDOI
Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action.
Francisco Javier Álvarez-Martínez,Enrique Barrajón-Catalán,María Herranz-López,Vicente Micol +3 more
TL;DR: A review of the full spectrum of plant antimicrobial agents (plant compounds, extracts and essential oils) discovered from 2016 to 2021 and their potential to decrease bacterial resistance is presented in this paper.
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A review on antimicrobial botanicals, phytochemicals and natural resistance modifying agents from Apocynaceae family: Possible therapeutic approaches against multidrug resistance in pathogenic microorganisms.
TL;DR: Three different paradigm models harnessing clinical antimicrobial resistance (AMR) including the plant family Apocynaceae, Gram-positive and Gram-negative bacterial species have been broadly discussed in this review.
References
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Journal ArticleDOI
Plant Products as Antimicrobial Agents
TL;DR: The current status of botanical screening efforts, as well as in vivo studies of their effectiveness and toxicity, are summarized and the structure and antimicrobial properties of phytochemicals are addressed.
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Molecular mechanisms of antibiotic resistance.
TL;DR: Recent advances in understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics are reviewed, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.
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Mechanisms of Antimicrobial Resistance in Bacteria
TL;DR: 3 case histories-one involving Escherichia coli resistance to third-generation cephalosporins, another focusing on the emergence of vancomycin-resistant Staphylococcus aureus, and a third detailing multidrug resistance in Pseudomonas aeruginosa--are reviewed to illustrate the varied ways in which resistant bacteria develop.
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Molecular mechanisms that confer antibacterial drug resistance
TL;DR: The authors live in an era when antibiotic resistance has spread at an alarming rate and dire predictions concerning the lack of effective antibacterial drugs occur with increasing frequency, so it is apposite to ask a few simple questions about these life-saving molecules.
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Proton-dependent multidrug efflux systems.
TL;DR: Whether the normal physiological role of the multidrug efflux systems is to protect the cell from toxic compounds or whether they fulfil primary functions unrelated to drug resistance and only efflux multiple drugs fortuitously or opportunistically is discussed.