Journal ArticleDOI
RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency
Miyoko Higuchi,Frank Nicolai Single,Martin Köhler,Bernd Sommer,Rolf Sprengel,Peter H. Seeburg +5 more
Reads0
Chats0
TLDR
Transfection of GluR-B gene constructs into PC12 cells revealed that the proximal part of the intron downstream of the unedited exonic site is required for Q/R site editing.About:
This article is published in Cell.The article was published on 1993-12-31. It has received 639 citations till now. The article focuses on the topics: RNA editing & Intron.read more
Citations
More filters
Journal Article
The glutamate receptor ion channels
TL;DR: The cloning of cDNAs encoding glutamate receptor subunits, which occurred mainly between 1989 and 1992, stimulated the development of ionotropic glutamate receptors in the brain.
Journal ArticleDOI
RNA-binding proteins and post-transcriptional gene regulation
TL;DR: The RBPs that interact with pre‐mRNAs and mRNAs are focused on and their roles in the regulation of post‐transcriptional gene expression are discussed.
Journal ArticleDOI
RNA Editing by Adenosine Deaminases That Act on RNA
TL;DR: This review summarizes ongoing investigations of the enzyme family and their substrates, focusing on biological function as well as biochemical mechanism.
Journal ArticleDOI
Glutamate receptors in the mammalian central nervous system
TL;DR: Recent progress in the research for GluRs is reviewed with special emphasis on the molecular diversity of the GluR system and its implications for physiology and pathology of the CNS.
Journal ArticleDOI
Functions and Regulation of RNA Editing by ADAR Deaminases
TL;DR: Recent findings that indicate new functions for A-->I editing in the regulation of noncoding RNAs and for interactions between RNA editing and RNA interference mechanisms are reviewed.
References
More filters
Journal ArticleDOI
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
Journal ArticleDOI
Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors
TL;DR: New Escherichia coli host strains have been constructed for the E. coli bacteriophage M13 and the high-copy-number pUC-plasmid cloning vectors and mutations introduced into these strains improve cloning of unmodified DNA and of repetitive sequences.
Book ChapterDOI
Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction.
Kary B. Mullis,Fred A. Faloona +1 more
TL;DR: A method whereby a nucleic acid sequence can be exponentially amplified in vitro is described in the chapter, and the possibility of utilizing a heat-stable DNA polymerase is explored so as to avoid the need for addition of new enzyme after each cycle of thermal denaturation.
Journal ArticleDOI
The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System
TL;DR: 'The following abbreviations have been used in the text'; I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu-cydupentyl-I,3-dicarbuxylate; AMPA, a aminU-3-hydruxy-5-methyl-isoxazole-4-propionate; AP4, 2-
Journal ArticleDOI
Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition
TL;DR: In neurons expressing certain KA-AMPA receptor subunits, glutamate may trigger calcium-dependent intracellular events by activating non-NMDA receptors.