Robust and durable serological response following pediatric SARS-CoV-2 infection
Hanna Renk,Alex Dulovic,Alina Seidel,Matthias Becker,Dorit Fabricius,Maria Zernickel,Daniel Junker,Rüdiger Groß,Janis A. Müller,Alexander Hilger,Sebastian F. N. Bode,Linus Fritsch,Pauline Frieh,A Haddad,Tessa Görne,Jonathan Remppis,Tina Ganzenmueller,Andrea N Dietz,Daniela Huzly,Hartmut Hengel,Klaus Kaier,Susanne Weber,Eva-Maria Jacobsen,Philipp D. Kaiser,Bjoern Traenkle,Ulrich Rothbauer,Maximilian Stich,Burkhard Tönshoff,G. F. Hoffmann,Barbara Müller,Carolin Ludwig,Bernd Jahrsdörfer,Hubert Schrezenmeier,Andreas Peter,Sebastian Hörber,Thomas Iftner,Jan Münch,Thomas Stamminger,Hans-Jürgen Groß,Martin Wolkewitz,Corinna Engel,Weimin Liu,Marta Rizzi,Beatrice H. Hahn,Philipp Henneke,Axel R. Franz,Klaus-Michael Debatin,Nicole Schneiderhan-Marra,Ales Janda,Roland Elling +49 more
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TLDR
In this paper , the authors examined 548 children and 717 adults within 328 households with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection.Abstract:
The quality and persistence of children's humoral immune response following SARS-CoV-2 infection remains largely unknown but will be crucial to guide pediatric SARS-CoV-2 vaccination programs. Here, we examine 548 children and 717 adults within 328 households with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection. We assess serological response at 3-4 months and 11-12 months after infection using a bead-based multiplex immunoassay for 23 human coronavirus antigens including SARS-CoV-2 and its Variants of Concern (VOC) and endemic human coronaviruses (HCoVs), and additionally by three commercial SARS-CoV-2 antibody assays. Neutralization against wild type SARS-CoV-2 and the Delta VOC are analysed in a pseudotyped virus assay. Children, compared to adults, are five times more likely to be asymptomatic, and have higher specific antibody levels which persist longer (96.2% versus 82.9% still seropositive 11-12 months post infection). Of note, symptomatic and asymptomatic infections induce similar humoral responses in all age groups. SARS-CoV-2 infection occurs independent of HCoV serostatus. Neutralization responses of children and adults are similar, although neutralization is reduced for both against the Delta VOC. Overall, the long-term humoral immune response to SARS-CoV-2 infection in children is of longer duration than in adults even after asymptomatic infection. read more
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Long-term Immune Response to SARS-CoV-2 Infection Among Children and Adults After Mild Infection
Costanza Di Chiara,Anna Cantarutti,Paola Costenaro,Daniele Donà,Francesco Bonfante,Chiara Cosma,Martina Ferrarese,Sandra Cozzani,Maria Raffaella Petrara,Francesco Carmona,Cecilia Liberati,Paolo Palma,G. Di Salvo,A. De Rossi,Mario Plebani,Andrea Padoan,Carlo Giaquinto +16 more
TL;DR: This study provided novel insights into the long-term features of the immune response to CO VID-19 for different age classes, which could help in optimizing future COVID-19 vaccination strategies and prevention policies.
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Continuous monitoring of SARS-CoV-2 seroprevalence in children using residual blood samples from routine clinical chemistry
Felix Wachter,Adrian P. Regensburger,Antonia Sophia Peter,Ferdinand Knieling,Alexandra L. Wagner,David Simon,André Hoerning,Joachim Woelfle,Klaus Überla,Antje Neubert,Manfred Rauh +10 more
TL;DR: It is suggested that residual blood samples from routine laboratory chemistry could be included in the estimation of the total SARS-CoV-2 seroprevalence in children.
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Long COVID symptoms in exposed and infected children, adolescents and their parents one year after SARS-CoV-2 infection: A prospective observational cohort study
A Haddad,Ales Janda,Hanna Renk,Maximilian Stich,Pauline Frieh,Klaus Kaier,Florens Lohrmann,Alexandra Nieters,A. Willems,Daniela Huzly,Alex Dulovic,Nicole Schneiderhan-Marra,Eva-Maria Jacobsen,Dorit Fabricius,Maria Zernickel,Thomas Stamminger,Sebastian F. N. Bode,Theda Himpel,Jonathan Remppis,Corinna Engel,Andreas Peter,Tina Ganzenmueller,Georg F. Hoffmann,Bettina Haase,Hans-Georg Kräusslich,Barbara Müller,Axel R. Franz,Klaus-Michael Debatin,Burkhard Tönshoff,Philipp Henneke,Roland Elling +30 more
TL;DR: In this paper , the authors examined long COVID symptoms in a cohort of infected children, adolescents, and adults and their exposed but non-infected household members approximately 1 year after infection and investigated clustering of persistent symptoms within households.
Journal ArticleDOI
Comparative Magnitude and Persistence of Humoral SARS-CoV-2 Vaccination Responses in the Adult Population in Germany
Alex Dulovic,Barbora Kessel,Manuela Harries,Matthias Becker,Julia Ortmann,Johanna Marie Griesbaum,Jennifer Jüngling,Daniel Junker,Pilar Hernández,Daniela Gornyk,Stephan Glöckner,Vanessa Melhorn,Stefanie Castell,Jana-Kristin Heise,Yvonne Kemmling,Torsten Tonn,Kerstin Frank,Thomas Illig,Norman Klopp,Neha Warikoo,Angelika Rath,C. Suckel,A. U. Marzian,Nicole Grupe,Philipp D. Kaiser,Bjoern Traenkle,Ulrich Rothbauer,Tobias Kerrinnes,Gérard Krause,Berit Lange,Nicole Schneiderhan-Marra,Monika Strengert +31 more
TL;DR: It is found that homologous mRNA-based or heterologous prime-boost vaccination produced significantly higher antibody responses than vector-based homologously vaccination, and vector- based vaccines resulted in an increased proportion of S2-targeting antibodies.
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Role of the humoral immune response during COVID-19: guilty or not guilty?
TL;DR: In this paper , the authors provide an overview of current knowledge about the humoral immune response to SARS-CoV-2, with a particular focus on the protective and pathological role of humoral immunity in COVID-19 severity.
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TL;DR: Most convalescent plasma samples obtained from individuals who recover from COVID-19 do not contain high levels of neutralizing activity, and rare but recurring RBD-specific antibodies with potent antiviral activity were found in all individuals tested, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.