Journal ArticleDOI
Role of VIP, PACAP, and related peptides in the regulation of the hypothalamo—pituitary–adrenal axis
Reads0
Chats0
TLDR
Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating (PACAP) are members of a family of regulatory peptides that are widely distributed in the body and share numerous biologic actions.Citations
More filters
Journal ArticleDOI
Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency
TL;DR: Prenatal diagnosis by direct mutation detection permits prenatal treatment of affected females with severe, classic 21-hydroxylase deficiency to minimize genital virilization, reducing mortality from this condition.
Journal Article
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions
TL;DR: The current knowledge concerning the multiple actions of PACAP in the central nervous system and in various peripheral organs including the endocrine glands, the airways, and the cardiovascular and immune systems are reviewed, as well as the different effects ofPACAP on a number of tumor cell types.
Journal ArticleDOI
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
David Vaudry,Anthony Falluel-Morel,Steve Bourgault,Magali Basille,Delphine Burel,Olivier Wurtz,Alain Fournier,Billy K. C. Chow,Hitoshi Hashimoto,Ludovic Galas,Hubert Vaudry +10 more
TL;DR: The present report reviews the current knowledge concerning the pleiotropic actions of PACAP and discusses its possible use for future therapeutic applications.
Journal ArticleDOI
Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
Journal ArticleDOI
Chronic Pain, Chronic Stress and Depression: Coincidence or Consequence?
TL;DR: The possible involvement of the HPA axis in the aetiology of both chronic pain and clinical depression is discussed, and a strategy for the development of novel pharmacotherapies is suggested.
References
More filters
Journal ArticleDOI
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells
Atsuro Miyata,Akira Arimura,Raymond R. Dahl,Naoto Minamino,Akira Uehara,Lun Jiang,M.D. Culler,David H. Coy +7 more
TL;DR: A novel neuropeptide which stimulates adenylate cyclase in rat anterior pituitary cell cultures was isolated from ovine hypothalamic tissues and increased release of growth hormone, prolactin, corticotropin and luteinizing hormone from superfused rat pituitaries at as small a dose as 10(-10)M) or 10(-9)M (LH).
Journal ArticleDOI
Polypeptide with Broad Biological Activity: Isolation from Small Intestine
Sami I. Said,Viktor Mutt +1 more
TL;DR: A polypeptide, which has potent and diverse biological action—including systemic vasodilation, hypotension, increased cardiac output, respiratory stimulation, and hyperglycemia—was isolated from the small intestine of the hog.
Journal ArticleDOI
Immune-neuro-endocrine interactions: facts and hypotheses.
Hugo O. Besedovsky,A del Rey +1 more
TL;DR: At the beginning of the second half of the 20th century, most efforts were directed at understanding the molecular and cellular basis of the immune response and the mechanisms of acquisition of immunologic responses.
Journal ArticleDOI
Differential signal transduction by five splice variants of the PACAP receptor
Dietmar Spengler,Christian Waeber,C Pantaloni,Florian Holsboer,Joël Bockaert,Peter H. Seeburg,Laurent Journot,Laurent Journot +7 more
TL;DR: A new expression cloning strategy, based on the induction of a reporter gene by cyclic AMP, is used to isolate a complementary DNA encoding the type-I PACAP receptor, suggesting a novel mechanism for fine tuning of signal transduction.
Journal ArticleDOI
Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38).
Atsuro Miyata,Lun Jiang,Raymond D. Dahl,Chieko Kitada,Kazuki Kubo,Masahiko Fujino,Naoto Minamino,Akira Arimura +7 more
TL;DR: Synthetic PACAP27 which shows a considerable homology with vasoactive intestinal polypeptide (VIP) demonstrated a similar vasodepressor activity as VIP, but the adenylate cyclase stimulating activity was about 1000 times greater than VIP.