Roles of Wnt proteins in neural development and maintenance.
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TLDR
Wnts have been shown to regulate the anatomy of the neuronal cytoskeleton and the differentiation of synapses in the cerebellum and may participate in degenerative processes leading to cell death in the aging brain.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2000-06-01 and is currently open access. It has received 305 citations till now. The article focuses on the topics: Wnt signaling pathway & Frizzled.read more
Citations
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The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling.
Carol A. Grimes,Richard S. Jope +1 more
TL;DR: GSK3beta has a central role regulating neuronal plasticity, gene expression, and cell survival, and may be a key component of certain psychiatric and neurodegenerative diseases.
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Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors
Silvia Maretto,Michelangelo Cordenonsi,Sirio Dupont,Paola Braghetta,Vania Broccoli,A. Bassim Hassan,Dino Volpin,Giorgio M. Bressan,Stefano Piccolo +8 more
TL;DR: BAT-gal mice unveil the entire complexity of Wnt/β-catenin signaling in mammals and have broad application potentials for the identification of WNT-responsive cell populations in development and disease.
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New aspects of Wnt signaling pathways in higher vertebrates
Joerg Huelsken,Walter Birchmeier +1 more
TL;DR: This review focuses on recent studies of mutant phenotypes in Mouse and Zebrafish which implicate members of the Wnt pathway in processes such as axis and mesoderm formation, initiation of organ development and stem cell differentiation.
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Wnt signaling induces the myogenic specification of resident CD45+ adult stem cells during muscle regeneration.
TL;DR: The data suggest that mobilization of resident CD45(+) stem cells is an important factor in regeneration after injury and highlight the Wnt pathway as a potential therapeutic target for degenerative neuromuscular disease.
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A morphogen gradient of Wnt/β-catenin signalling regulates anteroposterior neural patterning in Xenopus
Clemens Kiecker,Christof Niehrs +1 more
TL;DR: The results indicate that an activity gradient of Wnt/beta-catenin signalling acts as transforming morphogen to pattern the Xenopus central nervous system.
References
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β‐catenin is a target for the ubiquitin–proteasome pathway
TL;DR: It is shown that ubiquitination of β‐catenin is greatly reduced in Wnt‐expressing cells, providing the first evidence that the ubiquitin–proteasome degradation pathway may act downstream of GSK3β in the regulation ofβ‐ catenin.
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Mechanisms of wnt signaling in development
Andreas Wodarz,Roel Nusse +1 more
TL;DR: Over the past two years the understanding of Wnt signaling has been substantially improved by the identification of Frizzled proteins as cell surface receptors for Wnts and by the finding that beta-catenin, a component downstream of the receptor, can translocate to the nucleus and function as a transcriptional activator.
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Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
TL;DR: Dkk-1 is a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.
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The SCFβ-TRCP–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro
TL;DR: The transcription factor NF-κB has a central role in cellular stress and inflammatory responses by controlling cytokine-inducible gene expression and lymphocyte stimulation by antigens and little is known about the molecules responsible for ubiquitination.
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The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.
Stefano Piccolo,Stefano Piccolo,Eric Agius,Luc Leyns,Luc Leyns,Subha Bhattacharyya,Horst Grunz,Tewis Bouwmeester,E. M. De Robertis +8 more
TL;DR: In order for the head territory to form, it is proposed that signals involved in trunk development, such as those involving BMP, Wnt and Nodal proteins, must be inhibited in rostral regions.