Journal ArticleDOI
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
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TLDR
Results show thatβ-catenin can function in the decision of precursors to proliferate or differentiate during mammalian neuronal development and suggest that β-catanin can regulate cerebral cortical size by controlling the generation of neural precursor cells.Abstract:
Transgenic mice expressing a stabilized β-catenin in neural precursors develop enlarged brains with increased cerebral cortical surface area and folds resembling sulci and gyri of higher mammals. Brains from transgenic animals have enlarged lateral ventricles lined with neuroepithelial precursor cells, reflecting an expansion of the precursor population. Compared with wild-type precursors, a greater proportion of transgenic precursors reenter the cell cycle after mitosis. These results show that β-catenin can function in the decision of precursors to proliferate or differentiate during mammalian neuronal development and suggest that β-catenin can regulate cerebral cortical size by controlling the generation of neural precursor cells.read more
Citations
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Wnt signalling in stem cells and cancer
Tannishtha Reya,Hans Clevers +1 more
TL;DR: Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.
Journal ArticleDOI
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Tannishtha Reya,Andrew W. Duncan,Laurie Ailles,Jos Domen,David C. Scherer,Karl Willert,Lindsay Hintz,Roel Nusse,Irving L. Weissman +8 more
TL;DR: It is concluded that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and insight is provided into a potential molecular hierarchy of regulation of HSC development.
Journal ArticleDOI
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
Noboru Sato,Laurent Meijer,Laurent Meijer,Leandros Skaltsounis,Paul Greengard,Ali H. Brivanlou +5 more
TL;DR: It is shown that activation of the canonical Wnt pathway is sufficient to maintain self-renewal of both HESCs and MESCs, and the use of GSK-3-specific inhibitors such as BIO may have practical applications in regenerative medicine.
Journal ArticleDOI
Socializing with the Neighbors: Stem Cells and Their Niche
TL;DR: This review, which examines adult stem cell niches and their impact on stem cell biology, highlights the importance of understanding how stem cells interact with their microenvironment to establish and maintain their properties.
Journal ArticleDOI
The cell biology of neurogenesis.
TL;DR: In this paper, the authors discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.
References
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Thomas Scholzen,Johannes Gerdes +1 more
TL;DR: Although the Ki‐67 protein is well characterized on the molecular level and extensively used as a proliferation marker, the functional significance still remains unclear; there are indications, however, that Ki‐ 67 protein expression is an absolute requirement for progression through the cell‐division cycle.
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Journal ArticleDOI
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Journal ArticleDOI
Mice Lacking p27Kip1 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors
Keiko Nakayama,Keiko Nakayama,Noriko Ishida,Michiko Shirane,Akira Inomata,Tomoaki Inoue,Nobuyuki Shishido,Ikuo Horii,Dennis Y. Loh,Dennis Y. Loh,Keiichi I. Nakayama,Keiichi I. Nakayama +11 more
TL;DR: Findings indicate that p27(Kip1) acts to regulate the growth of a variety of cells, and surprises us by keeping the cell cycle arrest mediated by TGFbeta, rapamycin, or contact inhibition intact in p27(-/-) cells.