ROS homeostasis and metabolism: a dangerous liason in cancer cells.
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TLDR
How the mitochondria has a key role in regulating the interplay between redox homeostasis and metabolism within tumor cells is described, and the potential therapeutic use of agents that directly or indirectly block metabolism is discussed.Abstract:
Tumor cells harbor genetic alterations that promote a continuous and elevated production of reactive oxygen species. Whereas such oxidative stress conditions would be harmful to normal cells, they facilitate tumor growth in multiple ways by causing DNA damage and genomic instability, and ultimately, by reprogramming cancer cell metabolism. This review outlines the metabolic-dependent mechanisms that tumors engage in when faced with oxidative stress conditions that are critical for cancer progression by producing redox cofactors. In particular, we describe how the mitochondria has a key role in regulating the interplay between redox homeostasis and metabolism within tumor cells. Last, we will discuss the potential therapeutic use of agents that directly or indirectly block metabolism.read more
Citations
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Journal ArticleDOI
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents.
Helmut Sies,Dean P. Jones +1 more
TL;DR: This work focuses on ROS at physiological levels and their central role in redox signalling via different post-translational modifications, denoted as ‘oxidative eustress’.
Journal ArticleDOI
ROS signalling in the biology of cancer.
TL;DR: The generation and sources of ROS within tumour cells, the regulation of ROS by antioxidant defence systems, as well as the effect of elevated ROS production on their signalling targets in cancer are discussed.
Journal ArticleDOI
ROS in cancer therapy: the bright side of the moon
Bruno Perillo,Marzia Di Donato,Antonio Pezone,Erika Di Zazzo,Pia Giovannelli,Giovanni Galasso,Gabriella Castoria,Antimo Migliaccio +7 more
TL;DR: The review will emphasize the molecular mechanisms useful for the development of therapeutic strategies that are based on modulating ROS levels to treat cancer, and report on the growing data that highlight the role of ROS generated by different metabolic pathways as Trojan horses to eliminate cancer cells.
Journal ArticleDOI
Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling.
TL;DR: Studies in model organisms and humans are discussed, which reveal the dual roles of SOD enzymes in controlling damage and regulating signaling and the need for fine local control of ROS signaling.
Journal ArticleDOI
ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
Anastasiya V. Snezhkina,Anna V. Kudryavtseva,Olga L. Kardymon,Maria V Savvateeva,Nataliya V. Melnikova,George S. Krasnov,Alexey A. Dmitriev +6 more
TL;DR: This review covers the current data on the mechanisms of ROS generation and existing antioxidant systems balancing the redox state in mammalian cells that can also be related to tumors.
References
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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
EE Chouchani,Pell,Edoardo Gaude,Dunja Aksentijevic,Stephanie Y. Sundier,Michael R. Duchen,Michael J. Shattock,Christian Frezza,Thomas Krieg,Michael P. Murphy +9 more
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