Safety of Probiotics That Contain Lactobacilli or Bifidobacteria
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TLDR
Vigilance regarding the detection of possible rare cases of infection due to probiotics should be maintained, and isolates should be sent to reference centers for molecular characterization and confirmation.Abstract:
Lactobacilli and bifidobacteria are extremely rare causes of infection in humans, as are probiotics based on these organisms. This lack of pathogenicity extends across all age groups and to immunocompromised individuals. Strains used for new probiotics should be chosen from the commensal flora of humans and should not carry intrinsic resistance to antibiotics that would prevent treatment of a rare probiotic infection. Vigilance regarding the detection of possible rare cases of infection due to probiotics should be maintained, and isolates should be sent to reference centers for molecular characterization and confirmation.read more
Citations
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Journal ArticleDOI
Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens
TL;DR: There is increasing evidence that lactobacilli and bifidobacteria, which inhabit the gastrointestinal microbiota, develop antimicrobial activities that participate in the host's gastrointestinal system of defence.
Book ChapterDOI
Probiotics, Prebiotics, and Synbiotics
TL;DR: According to the German definition, probiotic microorganisms are defined viable microorganisms, sufficient amounts of which reach the intestine in an active state and thus exert positive health effects as mentioned in this paper.
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Probiotic use in clinical practice: what are the risks?
TL;DR: Although probiotics have an excellent overall safety record, they should be used with caution in certain patient groups-particularly neonates born prematurely or with immune deficiency, and further investigation is needed in these areas.
Journal ArticleDOI
Food fermentations: Microorganisms with technological beneficial use
F Bourdichon,Serge Casaregola,Choreh Farrokh,Jens Christian Frisvad,Monica L. Gerds,Walter P. Hammes,James Harnett,Geert Huys,Svend Laulund,Arthur C. Ouwehand,Ian B. Powell,Jashbhai B. Prajapati,Yasuyuki Seto,Eelko Ter Schure,Aart Van Boven,Vanessa Vankerckhoven,Annabelle Zgoda,Sandra Tuijtelaars,Egon Bech Hansen +18 more
TL;DR: An updated inventory of microorganisms used in food fermentations covering a wide range of food matrices and the taxonomy is reviewed and updated in order to bring theTaxonomy in agreement with the current standing in nomenclature.
Journal ArticleDOI
Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits
TL;DR: The traditional use of bifidobacteria in fermented dairy products and the GRAS status of certain strains attest to their safety, and some strains show high gastrointestinal survival capacity and exhibit probiotic properties in the colon.
References
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Journal ArticleDOI
Demonstration of safety of probiotics — a review
Seppo Salminen,Lorenzo Morelli,Philippe Marteau,W.M. de Vos,Rangne Fonden,Maija Saxelin,K. Collins,G. Mogensen,S.E. Birkeland,Tiina Mattila-Sandholm +9 more
TL;DR: Prior to incorporating new strains into products their efficacy should be carefully assessed, and a case by case evaluation as to whether they share the safety status of traditional food-grade organisms should be made.
Journal ArticleDOI
Taxonomy and important features of probiotic microorganisms in food and nutrition
TL;DR: Molecular typing methods such as pulsed-field gel electrophoresis, repetitive polymerase chain reaction, and restriction fragment length polymorphism are extremely valuable for specific characterization and detection of such strains selected for application as probiotics.
Journal ArticleDOI
Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial.
Stefano Guandalini,Licia Pensabene,M A Zikri,J. A. Dias,L G Casali,H Hoekstra,Sanja Kolaček,K Massar,Dušanka Mičetić-Turk,Alexandra Papadopoulou,J S de Sousa,Bhupinder Sandhu,Hania Szajewska,Zvi Weizman +13 more
TL;DR: Administering oral rehydration solution containing Lactobacillus GG to children with acute diarrhea is safe and results in shorter duration of diarrhea, less chance of a protracted course, and faster discharge from the hospital.
Journal ArticleDOI
Lactobacillus Bacteremia during a Rapid Increase in Probiotic Use of Lactobacillus rhamnosus GG in Finland
Minna K. Salminen,Soile Tynkkynen,Hilpi Rautelin,Maija Saxelin,Martti Vaara,Petri Ruutu,Seppo Sarna,Ville Valtonen,Asko Järvinen +8 more
TL;DR: The results indicate that increased probiotic use of L. rhamnosus GG has not led to an increase in Lactobacillus bacteremia.