Saliva: diagnostics and therapeutic perspectives.
Nadine Spielmann,David T.W. Wong +1 more
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TLDR
The avenue of saliva diagnostics incorporating transcriptomic, proteomic and metabolomic findings will enable us to connect salivary molecular analytes to monitor therapies, therapeutic outcomes, and finally disease progression in cancer.Abstract:
For the past two decades, salivary diagnostic approaches have been developed to monitor oral diseases such as periodontal diseases and to assess caries risk. Recently, the combination of emerging biotechnologies and salivary diagnostics has extended the range of saliva-based diagnostics from the oral cavity to the whole physiologic system as most compounds found in blood are also present in saliva. Accordingly, saliva can reflect the physiologic state of the body, including emotional, endocrinal, nutritional and metabolic variations and acts as a source for the monitoring of oral and also systemic health. This review presents an update on the status of saliva diagnostics and delves into their applications to the discovery of biomarkers for cancer detection and therapeutic applications. Translating scientific findings of nucleic acids, proteins and metabolites in body fluids to clinical applications is a cumbersome and challenging journey. Our research group is pursuing the biology of salivary analytes and the development of technologies for detection of distinct biomarkers with high sensitivity and specificity. The avenue of saliva diagnostics incorporating transcriptomic, proteomic and metabolomic findings will enable us to connect salivary molecular analytes to monitor therapies, therapeutic outcomes, and finally disease progression in cancer.read more
Citations
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Análise bioquímica das alterações salivares relacionadas à adaptação funcional de pacientes usuários de próteses totais
TL;DR: In this article, a trabalho foi avaliar modificacoes em parâmetros bioquimicos (niveis de oxido nitrico and cortisol salivares) in saliva of usuarios de proteses and verificar their associacao with clinicos como niveis of adaptacao funcional, traumatismos, fluxo salivar, and viscosidade.
Journal ArticleDOI
Variation in Salivary Parameters with Respect to Caries Status among Study Subjects
TL;DR: Saliva is a complex biological fluid containing several compounds which collaborate to prevent dental caries by mechanical washing, antimicrobial function, remineralisation and regulating oral pH by its buffering capacity.
Journal ArticleDOI
Chemiluminescent and bioluminescent markers of human physical health
Oksana A. Kolenchukova,Valentina A. Kratasyuk,Nadezhda N. Medvedeva,S. N. Derevtsova,L.V. Sindeeva,A. A. Romanenko,I.V. Turlak,E. M. Ryzhikova +7 more
TL;DR: In this paper , the authors present a survey of the state-of-the-art technologies used in the field of cyber-physical learning and propose a method to use them to train a classifier for the first time.
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Estimation of Salivary pH, Salivary Amylase in Patients with Oral cancer, Pre and Postoperatively -A Comparative Study
TL;DR: There was an increase in salivary pH postoperatively and decrease in Salivary amylase levels in post operatively, which is a reasonable method of assessing a patient's risk of disease onset, severity, and prognosis.
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