Journal ArticleDOI
Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex.
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TLDR
Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.Abstract:
The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.read more
Citations
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First-Row Transition Metal (De)Hydrogenation Catalysis Based On Functional Pincer Ligands.
TL;DR: This review aims at providing a comprehensive picture of the utilization of functional pincer ligands in first-row transition metal hydrogenation and dehydrogenation catalysis and related synthetic concepts relying on these such as the hydrogen borrowing methodology.
Journal ArticleDOI
Catalytic (de)hydrogenation promoted by non-precious metals – Co, Fe and Mn: recent advances in an emerging field
Georgy A. Filonenko,Georgy A. Filonenko,Robbert van Putten,Robbert van Putten,Emiel J. M. Hensen,Evgeny A. Pidko,Evgeny A. Pidko +6 more
TL;DR: This review is aimed at introducing the reader to the remarkable progress made in the last three years in the development of base metal catalysts for hydrogenations and dehydrogenative transformations.
Journal ArticleDOI
Selective Catalytic Hydrogenations of Nitriles, Ketones, and Aldehydes by Well-Defined Manganese Pincer Complexes
Saravanakumar Elangovan,Christoph Topf,Steffen Fischer,Haijun Jiao,Anke Spannenberg,Wolfgang Baumann,Ralf Ludwig,Kathrin Junge,Matthias Beller +8 more
TL;DR: This study describes for the first time specific molecular-defined manganese complexes that allow for the hydrogenation of various polar functional groups and achieves good functional group tolerance, and industrially important substrates, e.g., for the flavor and fragrance industry, are selectively reduced.
Journal ArticleDOI
Homogeneous Catalysis by Cobalt and Manganese Pincer Complexes
Arup Mukherjee,David Milstein +1 more
TL;DR: In this paper, a review of recent progress in the field of homogeneously catalyzed reactions using pincer-type complexes of cobalt and manganese is presented, including acceptorless dehydrogenation, hydrogenation, dehydrogenative coupling, hydrogen borrowing, hydrogen transfer, H-X additions, C-C coupling, alkene polymerization and N2 fixation.
Journal ArticleDOI
Manganese-Catalyzed Environmentally Benign Dehydrogenative Coupling of Alcohols and Amines to Form Aldimines and H2: A Catalytic and Mechanistic Study.
Arup Mukherjee,Alexander Nerush,Gregory Leitus,Linda J. W. Shimon,Yehoshoa Ben David,Noel Angel Espinosa Jalapa,David Milstein +6 more
TL;DR: This work presents the dehydrogenative coupling of alcohols and amines to form imines and H2 that is catalyzed, for the first time, by a complex of the earth-abundant Mn.
References
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Journal ArticleDOI
Hydroamination: direct addition of amines to alkenes and alkynes.
TL;DR: Hydroamination of Alkenes and Alkynes under Microwave Irradiation and Nitromercuration Reactions 3878 9.8.4.5.
Journal ArticleDOI
Metal-Initiated Amination of Alkenes and Alkynes.
Thomas Müller,Matthias Beller +1 more
TL;DR: The catalytic production of organic molecules is one of the most important applications of organometallic chemistry and enantioselective syntheses of molecules bearing an amine functionality use classical stoichiometric reactions with chiral auxiliaries or utilize enantiomerically pure starting material.
Journal ArticleDOI
Carbon–heteroatom bond formation catalysed by organometallic complexes
TL;DR: New elementary reactions that occur at metal–heteroatom bonds and the identification of factors that control these reactions have led to new synthetic processes that are in daily use and have formed a foundation for the development of processes likely to be central to synthetic chemistry in the future.
Journal ArticleDOI
Enantioselective Organocatalytic Reductive Amination
TL;DR: This new protocol realizes a key benefit of reductive amination versus imine reduction, in that ketimines derived from alkyl-alkyl ketones are unstable to isolation, a fundamental limitation that is comprehensively bypassed using this direct organocatalytic reductiveAmination.
Book
Handbook of Heterogeneous Catalytic Hydrogenation for Organic Synthesis
TL;DR: Handbook of heterogeneous catalytic hydrogenation for organic synthesis as discussed by the authors, Handbook of HHC for synthesis of organic molecules, and Handbook of CFI for the synthesis of synthetic molecules.