Journal ArticleDOI
Serious infections in patients with inflammatory bowel disease receiving anti-tumor-necrosis-factor-alpha therapy: an Australian and New Zealand experience.
Ian C. Lawrance,Graham L. Radford-Smith,Graham L. Radford-Smith,Peter A. Bampton,Jane M. Andrews,Pok-Kern Tan,Anthony Croft,Richard B. Gearry,Timothy H. Florin +8 more
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The aim of this study was to examine the Australian/New Zealand experience of serious infections and TB in IBD patients receiving anti‐TNF‐α therapy from 1999–2009.Abstract:
Ian C Lawrance, Graham L Radford-Smith, Peter A Bampton, Jane M Andrews, Pok-Kern Tan, Anthony Croft, Richard B Gearry and Timothy H J Florinread more
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Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders.
Fernando Magro,Paolo Gionchetti,Rami Eliakim,Sandro Ardizzone,Alessandro Armuzzi,Manuel Barreiro-de Acosta,Johan Burisch,Krisztina Gecse,Ailsa Hart,Pieter Hindryckx,Cord Langner,Jimmy K. Limdi,Gianluca Pellino,Edyta Zagórowicz,Tim Raine,Marcus Harbord,Florian Rieder +16 more
TL;DR: This research presents a meta-analyses of Gastroenterology and Hepatology at the cellular and molecular level, which shows clear trends in the development of immune-oncology-metabolical pathways towards “clinically checkpoints”.
Journal ArticleDOI
TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future
TL;DR: The therapeutic modulation of TNF now moves into the era of personalized medicine with society's challenging expectations of durable treatment success and of achieving long-term disease remission.
Journal ArticleDOI
Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease
Giovanni Monteleone,Markus F. Neurath,Sandro Ardizzone,Antonio Di Sabatino,Massimo Fantini,Fabiana Castiglione,Maria Lia Scribano,Alessandro Armuzzi,Flavio Caprioli,Giacomo Carlo Sturniolo,Francesca Rogai,Maurizio Vecchi,Raja Atreya,Fabrizio Bossa,Sara Onali,Maria Fichera,Gino Roberto Corazza,Livia Biancone,Vincenzo Savarino,Roberta Pica,Ambrogio Orlando,Francesco Pallone +21 more
TL;DR: It was found that study participants with Crohn's disease who received mongersen had significantly higher rates of remission and clinical response than those who received placebo.
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Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition.
Dan Turner,Frank M. Ruemmele,Esther Orlanski-Meyer,Anne M. Griffiths,Javier Martín de Carpi,Jiri Bronsky,Gábor Veres,Marina Aloi,Caterina Strisciuglio,Christian Braegger,Amit Assa,Claudio Romano,Seamus Hussey,Michael Stanton,Mikko P. Pakarinen,Lissy de Ridder,Konstantinos H. Katsanos,Nicholas M. Croft,Víctor Manuel Navas-López,David C. Wilson,Sally Lawrence,Richard K. Russell +21 more
TL;DR: These guidelines provide a guide to clinicians managing children with UC and IBD-unclassified management to provide modern management strategies while maintaining vigilance around appropriate outcomes and safety issues.
Journal ArticleDOI
Infection risk associated with anti-TNF-α agents: a review
Giuseppe Murdaca,Francesca Spanò,Miriam Contatore,Andrea Guastalla,Elena Penza,Ottavia Magnani,Francesco Puppo +6 more
TL;DR: Patients who are at high risk of herpes zoster reactivation would benefit from a second vaccination in adulthood when receiving TNF-α inhibitors and the strategies for mitigating against the development of these serious adverse events are discussed.
References
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Adalimumab improves joint-related and skin-related functional impairment in patients with psoriatic arthritis: patient-reported outcomes of the Adalimumab Effectiveness in Psoriatic Arthritis Trial
Dafna D. Gladman,Philip J. Mease,Mary A. Cifaldi,Renee J. Perdok,Eric H. Sasso,John R. Medich +5 more
TL;DR: Adalimumab improved physical-related and dermatological-related functional limitations, HRQOL, fatigue and pain in patients with PsA treated for 24 weeks.
Journal ArticleDOI
Risk factors for opportunistic infections in infliximab-treated patients: the importance of screening in prevention.
Carolina Garcia-Vidal,S. Rodríguez-Fernández,S. Teijón,Maria Esteve,Mónica Rodríguez-Carballeira,J. M. Lacasa,G Salvador,Javier Garau +7 more
TL;DR: The subset of patients treated with infliximab who had a higher risk for OI were identified and the screening of latent infections is key to diminishing the incidence of these infections.
Journal ArticleDOI
Herpes zoster in patients taking TNFα antagonists for chronic inflammatory joint disease
TL;DR: In this article, a retrospective review of the medical records of 300 patients who received TNFα antagonists to treat chronic inflammatory joint disease was performed to assess the rate of occurrence and outcomes of herpes zoster.
Journal ArticleDOI
Efficacy of adalimumab for the management of Inflammatory Bowel Disease in the Clinical Setting
TL;DR: Adalimumab has been available through the Australian Pharmaceutical Benefits Scheme since August 2008, but clinical experience for inflammatory bowel disease (IBD) in Australia is limited.
Journal Article
Tuberculosis epidemiology in New Zealand: 1995-2004.
TL;DR: The epidemiology of tuberculosis (TB) in New Zealand for the 10-year period 1995-2004 is described and TB case fatality and mortality rates in NZ are declining and are comparable to those in Australia, Canada, USA, and the UK.
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European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease.
Jean-François Rahier,Fernando Magro,Candida Abreu,Alessandro Armuzzi,Shomron Ben-Horin,Yehuda Chowers,Mario Cottone,L. de Ridder,Glen A. Doherty,Robert Ehehalt,Maria Esteve,K.H. Katsanos,Charlie W. Lees,Eithne MacMahon,Tom G. Moreels,Walter Reinisch,Herbert Tilg,Lydjie Tremblay,Gigi Veereman-Wauters,N. Viget,Yazdan Yazdanpanah,Rami Eliakim,Jean-Frederic Colombel +22 more