Journal ArticleDOI
Serious infections in patients with inflammatory bowel disease receiving anti-tumor-necrosis-factor-alpha therapy: an Australian and New Zealand experience.
Ian C. Lawrance,Graham L. Radford-Smith,Graham L. Radford-Smith,Peter A. Bampton,Jane M. Andrews,Pok-Kern Tan,Anthony Croft,Richard B. Gearry,Timothy H. Florin +8 more
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TLDR
The aim of this study was to examine the Australian/New Zealand experience of serious infections and TB in IBD patients receiving anti‐TNF‐α therapy from 1999–2009.Abstract:
Ian C Lawrance, Graham L Radford-Smith, Peter A Bampton, Jane M Andrews, Pok-Kern Tan, Anthony Croft, Richard B Gearry and Timothy H J Florinread more
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Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 1: Definitions, Diagnosis, Extra-intestinal Manifestations, Pregnancy, Cancer Surveillance, Surgery, and Ileo-anal Pouch Disorders.
Fernando Magro,Paolo Gionchetti,Rami Eliakim,Sandro Ardizzone,Alessandro Armuzzi,Manuel Barreiro-de Acosta,Johan Burisch,Krisztina Gecse,Ailsa Hart,Pieter Hindryckx,Cord Langner,Jimmy K. Limdi,Gianluca Pellino,Edyta Zagórowicz,Tim Raine,Marcus Harbord,Florian Rieder +16 more
TL;DR: This research presents a meta-analyses of Gastroenterology and Hepatology at the cellular and molecular level, which shows clear trends in the development of immune-oncology-metabolical pathways towards “clinically checkpoints”.
Journal ArticleDOI
TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future
TL;DR: The therapeutic modulation of TNF now moves into the era of personalized medicine with society's challenging expectations of durable treatment success and of achieving long-term disease remission.
Journal ArticleDOI
Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease
Giovanni Monteleone,Markus F. Neurath,Sandro Ardizzone,Antonio Di Sabatino,Massimo Fantini,Fabiana Castiglione,Maria Lia Scribano,Alessandro Armuzzi,Flavio Caprioli,Giacomo Carlo Sturniolo,Francesca Rogai,Maurizio Vecchi,Raja Atreya,Fabrizio Bossa,Sara Onali,Maria Fichera,Gino Roberto Corazza,Livia Biancone,Vincenzo Savarino,Roberta Pica,Ambrogio Orlando,Francesco Pallone +21 more
TL;DR: It was found that study participants with Crohn's disease who received mongersen had significantly higher rates of remission and clinical response than those who received placebo.
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Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition.
Dan Turner,Frank M. Ruemmele,Esther Orlanski-Meyer,Anne M. Griffiths,Javier Martín de Carpi,Jiri Bronsky,Gábor Veres,Marina Aloi,Caterina Strisciuglio,Christian Braegger,Amit Assa,Claudio Romano,Seamus Hussey,Michael Stanton,Mikko P. Pakarinen,Lissy de Ridder,Konstantinos H. Katsanos,Nicholas M. Croft,Víctor Manuel Navas-López,David C. Wilson,Sally Lawrence,Richard K. Russell +21 more
TL;DR: These guidelines provide a guide to clinicians managing children with UC and IBD-unclassified management to provide modern management strategies while maintaining vigilance around appropriate outcomes and safety issues.
Journal ArticleDOI
Infection risk associated with anti-TNF-α agents: a review
Giuseppe Murdaca,Francesca Spanò,Miriam Contatore,Andrea Guastalla,Elena Penza,Ottavia Magnani,Francesco Puppo +6 more
TL;DR: Patients who are at high risk of herpes zoster reactivation would benefit from a second vaccination in adulthood when receiving TNF-α inhibitors and the strategies for mitigating against the development of these serious adverse events are discussed.
References
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Tuberculosis infection in patients with rheumatoid arthritis and the effect of infliximab therapy
TL;DR: The rate of TB is not increased in RA patients generally and among infliximab-treated patients, the rate is 52.5 cases, and a thorough medical history regarding TB, as well as tuberculin testing and radiographic examination (if indicated), should be an essential component of anti-tumor necrosis factor therapy.
Journal ArticleDOI
Optimizing anti-TNF treatment in inflammatory bowel disease
TL;DR: Trial data suggest that systematic maintenance with 8 weekly doses of infliximab decreases the rate of complications, hospitalizations, and surgeries and these effects probably are achieved thanks to thorough healing of the bowel.
Journal ArticleDOI
Long-term safety of infliximab for the treatment of inflammatory bowel disease: a single-centre cohort study
Herma H. Fidder,F. Schnitzler,Marc Ferrante,Maja Noman,Konstantinos Katsanos,Siegfried Segaert,Liesbet Henckaerts,G. Van Assche,Severine Vermeire,Paul Rutgeerts +9 more
TL;DR: Long-term infliximab treatment had a good overall safety profile in the patient cohort studied, with no difference between the two groups in mortality, malignancies and infection rate.
Journal ArticleDOI
Treatment for rheumatoid arthritis and the risk of hospitalization for pneumonia: associations with prednisone, disease-modifying antirheumatic drugs, and anti-tumor necrosis factor therapy.
TL;DR: There is a dose-related relationship between prednisone use and pneumonia risk in rheumatoid arthritis and this data call into question the belief that low-doseprednisone is safe.
Journal ArticleDOI
Postmarketing surveillance of the safety profile of infliximab in 5000 Japanese patients with rheumatoid arthritis
Tsutomu Takeuchi,Yoshihiko Tatsuki,Y. Nogami,Naoki Ishiguro,Yoshiya Tanaka,Hisashi Yamanaka,Naoyuki Kamatani,Masayoshi Harigai,Junnosuke Ryu,K Inoue,Hirobumi Kondo,Shigeko Inokuma,Takahiro Ochi,Takao Koike +13 more
TL;DR: This postmarketing surveillance study of patients treated with infliximab showed that inflixIMab in combination with low-dose MTX was well tolerated in Japanese patients with active RA.
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European evidence-based Consensus on the prevention, diagnosis and management of opportunistic infections in inflammatory bowel disease.
Jean-François Rahier,Fernando Magro,Candida Abreu,Alessandro Armuzzi,Shomron Ben-Horin,Yehuda Chowers,Mario Cottone,L. de Ridder,Glen A. Doherty,Robert Ehehalt,Maria Esteve,K.H. Katsanos,Charlie W. Lees,Eithne MacMahon,Tom G. Moreels,Walter Reinisch,Herbert Tilg,Lydjie Tremblay,Gigi Veereman-Wauters,N. Viget,Yazdan Yazdanpanah,Rami Eliakim,Jean-Frederic Colombel +22 more