Serotonergic Dysfunction in Parkinson's Disease and Its Relevance to Disability
Marios Politis,Clare Loane +1 more
TLDR
In vivo findings indicate that agents acting on the serotonergic system could help towards alleviating the so-called nonmotor symptoms of Parkinson's disease, including depression, fatigue, weight changes, and visual hallucinations.Abstract:
Growing evidence suggests that Parkinson's disease is not solely affecting the dopaminergic system. Results from biochemical, animal, postmortem, and functional imaging studies have revealed that other neurotransmitter systems are affected as well, including the serotonergic system. With the use of in vivo positron emission tomography functional imaging, it has been shown that serotonergic terminals are affected at a varying, nonlinear degree starting early in the clinical course of Parkinson's disease. Tremor and the majority of nonmotor symptoms do not seem to respond adequately to dopaminergic medication. Recent studies suggest that serotonergic dysfunction has a direct relevance to Parkinson's disease symptoms, the so-called nonmotor symptoms, including depression, fatigue, weight changes, and visual hallucinations. These in vivo findings indicate that agents acting on the serotonergic system could help towards alleviating these symptoms. This paper aims to review the current literature and to highlight the need for further in vivo investigations.read more
Citations
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Serotonin in Parkinson's disease
Marios Politis,Flavia Niccolini +1 more
TL;DR: The current evidence with regards to the serotonergic pathology in Parkinson's disease and its relevance to the development of clinical symptoms is reviewed, primarily revising in vivo human studies from research with positron emission tomography molecular imaging.
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[Depression in Parkinson's disease].
TL;DR: In this paper, the authors present possible reasons for the development of depression in Parkinson's disease: psychological resulting from the presence and development of chronic disease as well as neurochemical disorders that reveal in this background.
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Buspirone: What is it all about?
Clare Loane,Marios Politis +1 more
TL;DR: It appears that buspirone may be useful in various other neurological and psychiatric disorders, such as attenuating side effects of Parkinson's disease therapy, ataxia, depression, social phobia, and behaviour disturbances following brain injury, and those accompanying Alzheimer's disease, dementia and attention deficit disorder.
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Visual hallucinations in Parkinson’s disease: a review and phenomenological survey: prospective study of hallucinations and delusions in Parkinson’s disease
TL;DR: In this article, a systematic literature search using standard electronic databases of published surveys and case-control studies was undertaken to summarise the factors most often associated with visual hallucination in Parkinson's disease and carry out a clinical comparison of ambulant patients with and without visual hallucinations.
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Psychedelics as anti-inflammatory agents.
TL;DR: Overall, psychedelics regulate inflammatory pathways via novel mechanisms, and may represent a new and exciting treatment strategy for several inflammatory disorders.
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