Sesquiterpene Coumarins from Ferula sinkiangensis Act as Neuroinflammation Inhibitors.
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TLDR
A bioactivity-guided phytochemical research was performed on the traditional Chinese medicine "Awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells, and identified sixteen bioactive sesquiterpene coumarins in the effective extract of Ferula sinkiangensis.Abstract:
Neuroinflammation mediated by microglia cells plays a critical role in the development of Alzheimer′s disease. To identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional Chinese medicine “Awei”, that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. The research identified sixteen bioactive sesquiterpene coumarins (two new and fourteen known ones) in the effective extract of Ferula sinkiangensis. Further, the anti-neuroinflammatory activities in BV-2 microglial cells were evaluated by monitoring LPS-induced nitric oxide production. In conclusion, the major constituent, (3′S, 5′S, 8′R, 9′S, 10′R)-kellerin (1.5 %, w/w), should be responsible for the anti-neuroinflammatory effect exhibited by Awei. Furthermore, it might be a potential natural therapeutic agent for Alzheimer′s disease. The research indicated moreover, that its primary mechanism is the inhibition of mRNA expression of the inflammatory cytokines nitric oxide, tumor necrosis factor-α, cyclooxygenase-2, interleukin-6 and interleukin-1β.read more
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The genus Ferula: ethnobotany, phytochemistry and bioactivities - a review
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A review of Ferula species: Biochemical characteristics, pharmaceutical and industrial applications, and suggestions for biotechnologists
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Recent Advances on Bioactive Constituents in Ferula.
TL;DR: The genus Ferula (Umbelliferea) is widely distributed across Central Asia and the Mediterranean and is a rich source of biologically active compounds, including coumarin derivatives, sesquiterpene-substituted compounds, daucane esters, humulane, and germacrane compounds, aromatic lactones and disulfide compounds as mentioned in this paper.
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Effects of Farnesiferol B on Ischemia-Reperfusion-Induced Renal Damage, Inflammation, and NF-κB Signaling
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TL;DR: Farnesiferol B might be a potent TGR5 ligand for the treatment of I/R-induced renal inflammation and could protect kidney function from ischemia/reperfusion-induced damage by attenuating inflammation though activating T GR5 in macrophages.
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