Sex influences in neurological disorders: case studies and perspectives.
TLDR
Case studies of neurological disorders affecting men and women, including multiple sclerosis and migraine, show strong sex differences in incidence and disease manifestation, to demonstrate the need for more such studies.Abstract:
Beginning in the late 1980s and early 1990s, scientists and the public alike recognized that, for too long, women had been underrepresented in clinical trials. While much progress was made in the following decades, preclinical research still often ignores sex as a fundamental biological variable. Many neurological disorders, including multiple sclerosis and migraine, show strong sex differences in incidence and disease manifestation. In this commentary, we highlight case studies of neurological disorders affecting men and women to demonstrate the need for more such studies. Research conducted in these areas so far has shed light on the underlying mechanisms of the disease and offers the promise to help develop more personalized treatments for both men and women.read more
Citations
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Effect of estrogen plus progestin on stroke in postmenopausal women: The Women's Health initiative: A randomized trial
Sylvia Wassertheil-Smoller,Susan L. Hendrix,Marian C. Limacher,Gerardo Heiss,Charles Kooperberg,Alison E. Baird,Theodore A. Kotchen,J. David Curb,Henry R. Black,Jacques E. Rossouw,Aaron K. Aragaki,Monika M. Safford,Evan A. Stein,Somchai Laowattana,W. Jerry Mysiw +14 more
TL;DR: Excess risk for all strokes attributed to estrogen plus progestin appeared to be present in all subgroups of women examined, and excess risk of all stroke was apparent in all age groups, in all categories of baseline stroke risk, and in women with and without hypertension, prior history of cardiovascular disease, use of hormones, statins, or aspirin.
Journal ArticleDOI
Sex differences in behavior and neuropharmacology of zebrafish.
Rafael Genario,Murilo S. de Abreu,Ana C.V.V. Giacomini,Konstantin A. Demin,Allan V. Kalueff,Allan V. Kalueff +5 more
TL;DR: The role of sex in zebrafish central nervous system (CNS) models, their molecular mechanisms, recent findings and the existing challenges are discussed, with a focus on the growing utility of zebra fish models in translational neuropharmacological research of sex differences.
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Root and Root Canal Morphology Differences Between Genders: A Comprehensive in-vivo CBCT Study in a Saudi Population.
TL;DR: No significant differences between both genders in relation to number of roots were found and three groups of teeth with females who had a smaller number of canals than males showed statistically significant differences.
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Microglial and Astrocytic Function in Physiological and Pathological Conditions: Estrogenic Modulation.
TL;DR: This review will highlight data about sex differences in glial physiology and how estrogenic compounds, such as estradiol and tibolone, could be used as treatment in neurological diseases due to their anti-inflammatory effects and the ability to modulate glial cell functions.
References
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Policy: NIH to balance sex in cell and animal studies
TL;DR: Policy to ensure that preclinical research funded by the US National Institutes of Health considers females and males is unveiled, with a focus on women and males.
Journal ArticleDOI
Sex bias in neuroscience and biomedical research
TL;DR: Sex bias in research on mammals in 10 biological fields for 2009 was evident in 8 disciplines and most prominent in neuroscience, with single-sex studies of male animals outnumbering those of females 5.5 to 1.5.
Journal ArticleDOI
Migraine and cardiovascular disease: systematic review and meta-analysis
Markus Schürks,Pamela M. Rist,Marcelo E. Bigal,Marcelo E. Bigal,Julie E. Buring,Richard B. Lipton,Tobias Kurth,Tobias Kurth,Tobias Kurth +8 more
TL;DR: Migraine is associated with a twofold increased risk of ischaemic stroke, which is only apparent among people who have migraine with aura, and the results suggest a higher risk among women and risk was further magnified for people with migraine who were aged less than 45, smokers, and women who used oral contraceptives.
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Sex Differences in the Clinical Presentation, Resource Use, and 3-Month Outcome of Acute Stroke in Europe: Data From a Multicenter Multinational Hospital-Based Registry
Antonio Di Carlo,Maria Lamassa,Marzia Baldereschi,Giovanni Pracucci,Anna Maria Basile,Charles D.A. Wolfe,Maurice Giroud,Anthony Rudd,Augusto Ghetti,Domenico Inzitari +9 more
TL;DR: Sex-specific differences existed in a large European study of hospital admissions for acute stroke and both medical and sociodemographic factors may significantly influence stroke outcome.